Summary: This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008].

Fc fragment of IgG receptor IIaMIM:146790Ensembl:ENSG00000143226HGNC:HGNC:3616PA280631q23.3

Gene Categories:


GO terms in FCGR2A

Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIEAGO:0019864IgG binding
CCTASGO:0005886plasma membrane
CCIEAGO:0016021integral component of membrane
CCTASGO:0030667secretory granule membrane
BPTASGO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis
BPTASGO:0043312neutrophil degranulation

Gene expression in normal tissue: FCGR2A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FCGR2A

DatabasePathway IDPathway Des.
pidintegrin2_pathwayBeta2 integrin cell surface interactions
pidptp1bpathwaySignaling events mediated by PTP1B
kegghsa04145Phagosome - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04611Platelet activation - Homo sapiens (human)
kegghsa04666Fc gamma R-mediated phagocytosis - Homo sapiens (human)
kegghsa05140Leishmaniasis - Homo sapiens (human)
kegghsa05150Staphylococcus aureus infection - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05322Systemic lupus erythematosus - Homo sapiens (human)
wikipathwaysWP2431Spinal Cord Injury
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosis
reactomeR-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosis
reactomeR-HSA-2029481FCGR activation
reactomeR-HSA-2029481FCGR activation
reactomeR-HSA-2029482Regulation of actin dynamics for phagocytic cup formation
reactomeR-HSA-2029485Role of phospholipids in phagocytosis
reactomeR-HSA-6798695Neutrophil degranulation

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FCGR2A