FCRL4
Summary: This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma. [provided by RefSeq, Apr 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Fc receptor like 4 | MIM:605876 | Ensembl:ENSG00000163518 | HGNC:HGNC:18507 | PA142671768 | 1q23.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in FCRL4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0002250 | adaptive immune response |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| CC | IEA | GO:0016021 | integral component of membrane |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: FCRL4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FCRL4
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD781 | Sirolimus | 4 |
| iGMDRD126 | Tipifarnib | 6 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD889 | Compound 7d-cis | 4 |
| iGMDRD280 | CYTOCHALASIN B | 4 |
| iGMDRD679 | Bistramide A | 4 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD60 | Quinoclamine | 5 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD871 | BRD6368 | 5 |
| iGMDRD780 | PP-30 | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FCRL4
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