Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. [provided by RefSeq, Jul 2008].

fibroblast growth factor 3MIM:164950Ensembl:ENSG00000186895HGNC:HGNC:3681PA2812011q13.3

GO terms in FGF3

Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005576extracellular region
BPTASGO:0000165MAPK cascade
BPTASGO:0007165signal transduction
BPTASGO:0007267cell-cell signaling
BPIEAGO:0007275multicellular organism development
BPIGIGO:0008284positive regulation of cell proliferation
BPIGIGO:0008543fibroblast growth factor receptor signaling pathway
BPTASGO:0008543fibroblast growth factor receptor signaling pathway
BPTASGO:0009653anatomical structure morphogenesis
BPIEAGO:0010469regulation of signaling receptor activity
BPIEAGO:0018108peptidyl-tyrosine phosphorylation
BPIEAGO:0030154cell differentiation
BPIEAGO:0036092phosphatidylinositol-3-phosphate biosynthetic process
BPIEAGO:0046854phosphatidylinositol phosphorylation
BPIEAGO:0051781positive regulation of cell division
BPTASGO:0051897positive regulation of protein kinase B signaling
BPIMPGO:0055026negative regulation of cardiac muscle tissue development
MFTASGO:0004713protein tyrosine kinase activity
MFTASGO:0005088Ras guanyl-nucleotide exchange factor activity
MFIEAGO:0005104fibroblast growth factor receptor binding
MFIPIGO:0005515protein binding
MFIEAGO:0008083growth factor activity
MFTASGO:00163031-phosphatidylinositol-3-kinase activity
MFTASGO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Gene expression in normal tissue: FGF3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FGF3

DatabasePathway IDPathway Des.
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05218Melanoma - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
wikipathwaysWP3584MECP2 and Associated Rett Syndrome
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP51Regulation of Actin Cytoskeleton
reactomeR-HSA-109704PI3K Cascade
reactomeR-HSA-112399IRS-mediated signalling
reactomeR-HSA-1226099Signaling by FGFR in disease
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1839126FGFR2 mutant receptor activation
reactomeR-HSA-190236Signaling by FGFR
reactomeR-HSA-190241FGFR2 ligand binding and activation
reactomeR-HSA-190242FGFR1 ligand binding and activation
reactomeR-HSA-190370FGFR1b ligand binding and activation
reactomeR-HSA-190377FGFR2b ligand binding and activation
reactomeR-HSA-199418Negative regulation of the PI3K/AKT network
reactomeR-HSA-2033519Activated point mutants of FGFR2
reactomeR-HSA-2219528PI3K/AKT Signaling in Cancer
reactomeR-HSA-2219530Constitutive Signaling by Aberrant PI3K in Cancer
reactomeR-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
reactomeR-HSA-2428924IGF1R signaling cascade
reactomeR-HSA-2428928IRS-related events triggered by IGF1R
reactomeR-HSA-5654219Phospholipase C-mediated cascade: FGFR1
reactomeR-HSA-5654221Phospholipase C-mediated cascade; FGFR2
reactomeR-HSA-5654687Downstream signaling of activated FGFR1
reactomeR-HSA-5654688SHC-mediated cascade:FGFR1
reactomeR-HSA-5654689PI-3K cascade:FGFR1
reactomeR-HSA-5654693FRS-mediated FGFR1 signaling
reactomeR-HSA-5654695PI-3K cascade:FGFR2
reactomeR-HSA-5654696Downstream signaling of activated FGFR2
reactomeR-HSA-5654699SHC-mediated cascade:FGFR2
reactomeR-HSA-5654700FRS-mediated FGFR2 signaling
reactomeR-HSA-5654726Negative regulation of FGFR1 signaling
reactomeR-HSA-5654727Negative regulation of FGFR2 signaling
reactomeR-HSA-5654736Signaling by FGFR1
reactomeR-HSA-5654738Signaling by FGFR2
reactomeR-HSA-5655253Signaling by FGFR2 in disease
reactomeR-HSA-5658623FGFRL1 modulation of FGFR1 signaling
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
reactomeR-HSA-74751Insulin receptor signalling cascade
reactomeR-HSA-74752Signaling by Insulin receptor
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FGF3