FHIT
Summary: The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| fragile histidine triad | MIM:601153 | Ensembl:ENSG00000189283 | HGNC:HGNC:3701 | PA28140 | 3p14.2 |
GO terms in FHIT
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0001650 | fibrillar center |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| BP | IDA | GO:0006163 | purine nucleotide metabolic process |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | TAS | GO:0009117 | nucleotide metabolic process |
| BP | IMP | GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | IMP | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator |
| MF | IEA | GO:0000166 | nucleotide binding |
| MF | TAS | GO:0003824 | catalytic activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0016787 | hydrolase activity |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IDA | GO:0047710 | bis(5'-adenosyl)-triphosphatase activity |
Gene expression in normal tissue: FHIT
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FHIT
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00230 | Purine metabolism - Homo sapiens (human) |
| kegg | hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD219 | Bax channel blocker | 6 |
| iGMDRD511 | CHEMBL399379 | 2 |
| iGMDRD123 | Isoevodiamine | 5 |
| iGMDRD329 | Merck60 | 6 |
| iGMDRD366 | PI-103 | 3 |
| iGMDRD367 | Ro 28-1675 | 4 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD871 | BRD6368 | 6 |
| iGMDRD147 | Prima-1 | 4 |
| iGMDRD552 | AZD-1775 | 2 |
| iGMDRD103 | SN-38 | 8 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD213 | SMR000068650 | 4 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD105 | Triptolide | 1 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD466 | Chaetocin | 4 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD889 | Compound 7d-cis | 5 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD433 | Lexibulin | 2 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD427 | ABT737 | 8 |
| iGMDRD224 | Necrostatin-1 | 2 |
| iGMDRD888 | Compound 44 | 2 |
| iGMDRD506 | Fedratinib | 11 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD524 | ISX-9 | 1 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD247 | Blebbistatin | 4 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD607 | Ubistatin B | 4 |
| iGMDRD148 | Pifithrin-mu | 6 |
| iGMDRD497 | 16beta-Bromoandrosterone | 1 |
| iGMDRD701 | NVP-AUY922 | 4 |
| iGMDRD882 | CIL41 | 2 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD886 | Compound 1541A | 1 |
| iGMDRD246 | NPC26 | 5 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD201 | SKI II | 1 |
| iGMDRD375 | GW-405833 | 4 |
| iGMDRD634 | SCHEMBL2608041 | 5 |
| iGMDRD380 | Pifithrin-alpha | 4 |
| iGMDRD280 | CYTOCHALASIN B | 7 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD772 | BRD4770 | 4 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD144 | NSC95397 | 8 |
| iGMDRD577 | BIX01294 | 9 |
| iGMDRD562 | Navitoclax | 10 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD268 | Cerulenin | 5 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD690 | PRIMA-1MET | 4 |
| iGMDRD60 | Quinoclamine | 10 |
| iGMDRD802 | 4-methylfasudil | 2 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD270 | Ciclosporin | 5 |
| iGMDRD138 | PX 12 | 1 |
| iGMDRD318 | PAC-1 | 4 |
| iGMDRD869 | BRD55319 | 1 |
| iGMDRD782 | DC-45-A2 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FHIT
CLASSFICATION
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