FNTB
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| farnesyltransferase, CAAX box, beta | MIM:134636 | Ensembl:ENSG00000257365 | HGNC:HGNC:3785 | PA28202 | 14q23.3 |
GO terms in FNTB
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0010035 | response to inorganic substance |
| BP | IEA | GO:0014070 | response to organic cyclic compound |
| BP | IBA | GO:0018342 | protein prenylation |
| BP | IBA | GO:0018343 | protein farnesylation |
| BP | IDA | GO:0018343 | protein farnesylation |
| BP | IEA | GO:0034097 | response to cytokine |
| BP | IEA | GO:0042060 | wound healing |
| BP | IEA | GO:0045787 | positive regulation of cell cycle |
| BP | IEA | GO:0048146 | positive regulation of fibroblast proliferation |
| BP | IEA | GO:0051770 | positive regulation of nitric-oxide synthase biosynthetic process |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005875 | microtubule associated complex |
| CC | IBA | GO:0005965 | protein farnesyltransferase complex |
| CC | IDA | GO:0005965 | protein farnesyltransferase complex |
| MF | IEA | GO:0004311 | farnesyltranstransferase activity |
| MF | IBA | GO:0004659 | prenyltransferase activity |
| MF | IBA | GO:0004660 | protein farnesyltransferase activity |
| MF | IDA | GO:0004660 | protein farnesyltransferase activity |
| MF | IDA | GO:0004660 | protein farnesyltransferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008144 | drug binding |
| MF | IDA | GO:0008270 | zinc ion binding |
| MF | IEA | GO:0019840 | isoprenoid binding |
| MF | IEA | GO:0042277 | peptide binding |
Gene expression in normal tissue: FNTB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FNTB
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-2187338 | Visual phototransduction |
| reactome | R-HSA-2514856 | The phototransduction cascade |
| reactome | R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| kegg | hsa00900 | Terpenoid backbone biosynthesis - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FNTB
CLASSFICATION
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