Summary: Members of the winged-helix/forkhead family of transcription factors, such as FOXN4, are characterized by a 110-amino acid DNA-binding domain that can fold into a variant of the helix-turn-helix motif consisting of 3 alpha helices flanked by 2 large loops or wings. These transcription factors are involved in a variety of biologic processes as key regulators in development and metabolism (Li et al., 2004 [PubMed 15363391]).[supplied by OMIM, Mar 2008].

forkhead box N4MIM:609429Ensembl:ENSG00000139445HGNC:HGNC:21399PA13498296512q24.11

GO terms in FOXN4

Term TypeEvidence TypeGO Term IDGO Des.
BPISSGO:0001947heart looping
BPIEAGO:0006351transcription, DNA-templated
BPISSGO:0006355regulation of transcription, DNA-templated
BPIEAGO:0006357regulation of transcription by RNA polymerase II
BPISSGO:0008016regulation of heart contraction
BPISSGO:0010842retina layer formation
BPISSGO:0035881amacrine cell differentiation
BPISSGO:0036302atrioventricular canal development
BPISSGO:0045893positive regulation of transcription, DNA-templated
BPISSGO:0060579ventral spinal cord interneuron fate commitment
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIDAGO:0001158enhancer sequence-specific DNA binding
MFISSGO:0001158enhancer sequence-specific DNA binding
MFISSGO:0003682chromatin binding
MFISSGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding

Gene expression in normal tissue: FOXN4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FOXN4

DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FOXN4