FOXN4
Summary: Members of the winged-helix/forkhead family of transcription factors, such as FOXN4, are characterized by a 110-amino acid DNA-binding domain that can fold into a variant of the helix-turn-helix motif consisting of 3 alpha helices flanked by 2 large loops or wings. These transcription factors are involved in a variety of biologic processes as key regulators in development and metabolism (Li et al., 2004 [PubMed 15363391]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| forkhead box N4 | MIM:609429 | Ensembl:ENSG00000139445 | HGNC:HGNC:21399 | PA134982965 | 12q24.11 |
GO terms in FOXN4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0001947 | heart looping |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | ISS | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0008016 | regulation of heart contraction |
| BP | ISS | GO:0010842 | retina layer formation |
| BP | ISS | GO:0035881 | amacrine cell differentiation |
| BP | ISS | GO:0036302 | atrioventricular canal development |
| BP | ISS | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | ISS | GO:0060579 | ventral spinal cord interneuron fate commitment |
| CC | ISS | GO:0005634 | nucleus |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0001158 | enhancer sequence-specific DNA binding |
| MF | ISS | GO:0001158 | enhancer sequence-specific DNA binding |
| MF | ISS | GO:0003682 | chromatin binding |
| MF | ISS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: FOXN4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FOXN4
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FOXN4
CLASSFICATION
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