FYB1
Summary: The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| FYN binding protein 1 | MIM:602731 | Ensembl:ENSG00000082074 | HGNC:HGNC:4036 | PA28452 | 5p13.1 |
GO terms in FYB1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008289 | lipid binding |
| MF | IEA | GO:0044877 | protein-containing complex binding |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0006607 | NLS-bearing protein import into nucleus |
| BP | IEA | GO:0006955 | immune response |
| BP | IBA | GO:0007165 | signal transduction |
| BP | TAS | GO:0007165 | signal transduction |
| BP | ND | GO:0008150 | biological_process |
| BP | TAS | GO:0035556 | intracellular signal transduction |
| BP | TAS | GO:0050852 | T cell receptor signaling pathway |
| BP | IEA | GO:0072659 | protein localization to plasma membrane |
| CC | IEA | GO:0005634 | nucleus |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0015629 | actin cytoskeleton |
| CC | IEA | GO:0030054 | cell junction |
Gene expression in normal tissue: FYB1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FYB1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
| netpath | Pathway_TCR | TCR |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-202403 | TCR signaling |
| reactome | R-HSA-202403 | TCR signaling |
| reactome | R-HSA-202433 | Generation of second messenger molecules |
| reactome | R-HSA-202433 | Generation of second messenger molecules |
| reactome | R-HSA-391160 | Signal regulatory protein family interactions |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FYB1
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.