GO terms in FZR1


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005680anaphase-promoting complex
CCTASGO:0005829cytosol
CCIDAGO:0031965nuclear membrane
BPIEAGO:0006281DNA repair
BPIEAGO:0007049cell cycle
BPIEAGO:0008284positive regulation of cell proliferation
BPIDAGO:0031145anaphase-promoting complex-dependent catabolic process
BPTASGO:0031145anaphase-promoting complex-dependent catabolic process
BPIEAGO:0040020regulation of meiotic nuclear division
BPIGIGO:0045732positive regulation of protein catabolic process
BPIEAGO:0051301cell division
BPIEAGO:0070306lens fiber cell differentiation
BPTASGO:0070979protein K11-linked ubiquitination
BPIDAGO:0072425signal transduction involved in G2 DNA damage checkpoint
BPIEAGO:0090344negative regulation of cell aging
BPIDAGO:1904668positive regulation of ubiquitin protein ligase activity
MFIPIGO:0005515protein binding
MFIEAGO:0010997anaphase-promoting complex binding
MFIEAGO:0097027ubiquitin-protein transferase activator activity

Gene expression in normal tissue: FZR1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FZR1


DatabasePathway IDPathway Des.
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-168256Immune System
reactomeR-HSA-174084Autodegradation of Cdh1 by Cdh1:APC/C
reactomeR-HSA-174113SCF-beta-TrCP mediated degradation of Emi1
reactomeR-HSA-174143APC/C-mediated degradation of cell cycle proteins
reactomeR-HSA-174178APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
reactomeR-HSA-176407Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
reactomeR-HSA-176408Regulation of APC/C activators between G1/S and early anaphase
reactomeR-HSA-176417Phosphorylation of Emi1
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-453276Regulation of mitotic cell cycle
reactomeR-HSA-69017CDK-mediated phosphorylation and removal of Cdc6
reactomeR-HSA-69052Switching of origins to a post-replicative state
reactomeR-HSA-69239Synthesis of DNA
reactomeR-HSA-69242S Phase
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69306DNA Replication
reactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entry
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-983168Antigen processing: Ubiquitination & Proteasome degradation
reactomeR-HSA-983169Class I MHC mediated antigen processing & presentation
kegghsa04110Cell cycle - Homo sapiens (human)
kegghsa04120Ubiquitin mediated proteolysis - Homo sapiens (human)
kegghsa04914Progesterone-mediated oocyte maturation - Homo sapiens (human)
pidaurora_a_pathwayAurora A signaling
pidplk1_pathwayPLK1 signaling events
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD512nutlin 34
iGMDRD405PIK-752
iGMDRD536PLX-47201
iGMDRD352PD-03259011
iGMDRD351GW843682X1
iGMDRD57Chloropentafluorobenzene2
iGMDRD211(1S,3R)-RSL32
iGMDRD672Alectinib1
iGMDRD271Brefeldin A1
iGMDRD121GMX17783
iGMDRD202Curcumin3
iGMDRD137Indisulam4
iGMDRD267Oligomycin A3
iGMDRD213SMR0000686501
iGMDRD329Merck604
iGMDRD136Nutlin-31
iGMDRD151CHM-12
iGMDRD12Bicalutamide4
iGMDRD579PF7502
iGMDRD670ML 2103
iGMDRD494Neopeltolide5
iGMDRD781Sirolimus3
iGMDRD446LY 21832402
iGMDRD639YK 4-2792
iGMDRD152179324-69-71
iGMDRD193Fqi12
iGMDRD198AC1LE7KD1
iGMDRD280CYTOCHALASIN B2
iGMDRD284Palbociclib1
iGMDRD782DC-45-A25
iGMDRD171Pemetrexed2
iGMDRD441TW 371
iGMDRD30917AAG1
iGMDRD133Lapatinib1
iGMDRD887Compound 23 citrate2
iGMDRD74Idarubicin2
iGMDRD399Selumetinib3
iGMDRD506Fedratinib2
iGMDRD780PP-302
iGMDRD64Parbendazole1
iGMDRD190Nilotinib1
iGMDRD369TGX-1152

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FZR1

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