Summary: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008].

growth arrest and DNA damage inducible gammaMIM:604949Ensembl:ENSG00000130222HGNC:HGNC:4097PA285129q22.2

GO terms in GADD45G

Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0000185activation of MAPKKK activity
BPIDAGO:0000185activation of MAPKKK activity
BPIEAGO:0006915apoptotic process
BPIEAGO:0006950response to stress
BPIEAGO:0007275multicellular organism development
BPIEAGO:0030154cell differentiation
BPIDAGO:0043065positive regulation of apoptotic process
BPIDAGO:0046330positive regulation of JNK cascade
BPIBAGO:0051726regulation of cell cycle
BPIDAGO:1900745positive regulation of p38MAPK cascade
MFIPIGO:0005515protein binding

Gene expression in normal tissue: GADD45G

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GADD45G

DatabasePathway IDPathway Des.
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04110Cell cycle - Homo sapiens (human)
kegghsa04115p53 signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05213Endometrial cancer - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
kegghsa05216Thyroid cancer - Homo sapiens (human)
kegghsa05217Basal cell carcinoma - Homo sapiens (human)
kegghsa05218Melanoma - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
kegghsa05222Small cell lung cancer - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
pidil12_2pathwayIL12-mediated signaling events
pidp38_mkk3_6pathwayp38 MAPK signaling pathway
wikipathwaysWP1530miRNA Regulation of DNA Damage Response
wikipathwaysWP4155Endometrial cancer
wikipathwaysWP4216Chromosomal and microsatellite instability in colorectal cancer
wikipathwaysWP707DNA Damage Response

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GADD45G