GBGT1
Summary: This gene encodes a glycosyltransferase that plays a role in the synthesis of Forssman glycolipid (FG), a member of the globoseries glycolipid family. Glycolipids such as FG form attachment sites for the binding of pathogens to cells; expression of this protein may determine host tropism to microorganisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group) | MIM:606074 | Ensembl:ENSG00000148288 | HGNC:HGNC:20460 | PA134967297 | 9q34.2 |
GO terms in GBGT1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0005975 | carbohydrate metabolic process |
| BP | IEA | GO:0006486 | protein glycosylation |
| BP | TAS | GO:0009247 | glycolipid biosynthetic process |
| BP | IBA | GO:0030259 | lipid glycosylation |
| CC | IEA | GO:0000139 | Golgi membrane |
| CC | IBA | GO:0005794 | Golgi apparatus |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IBA | GO:0031982 | vesicle |
| MF | IBA | GO:0016757 | transferase activity, transferring glycosyl groups |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IBA | GO:0047277 | globoside alpha-N-acetylgalactosaminyltransferase activity |
Gene expression in normal tissue: GBGT1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GBGT1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00603 | Glycosphingolipid biosynthesis - globo and isoglobo series - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GBGT1
CLASSFICATION
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