GCSAM
Summary: This gene encodes a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| germinal center associated signaling and motility | MIM:607792 | Ensembl:ENSG00000174500 | HGNC:HGNC:20253 | PA134980592 | 3q13.2 |
GO terms in GCSAM
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0050855 | regulation of B cell receptor signaling pathway |
| BP | IMP | GO:2000402 | negative regulation of lymphocyte migration |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005886 | plasma membrane |
| MF | IPI | GO:0003779 | actin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0045159 | myosin II binding |
Gene expression in normal tissue: GCSAM
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GCSAM
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GCSAM
CLASSFICATION
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