GDI1
Summary: GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific cognitive disability. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| GDP dissociation inhibitor 1 | MIM:300104 | Ensembl:ENSG00000203879 | HGNC:HGNC:4226 | PA28641 | Xq28 |
GO terms in GDI1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0005092 | GDP-dissociation inhibitor activity |
| MF | ISS | GO:0005093 | Rab GDP-dissociation inhibitor activity |
| MF | IEA | GO:0005096 | GTPase activator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0017137 | Rab GTPase binding |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0015031 | protein transport |
| BP | ISS | GO:0032482 | Rab protein signal transduction |
| BP | IEA | GO:0043547 | positive regulation of GTPase activity |
| BP | IEA | GO:0045773 | positive regulation of axon extension |
| BP | ISS | GO:0050771 | negative regulation of axonogenesis |
| BP | TAS | GO:0051056 | regulation of small GTPase mediated signal transduction |
| BP | IEA | GO:0051592 | response to calcium ion |
| BP | IMP | GO:0090315 | negative regulation of protein targeting to membrane |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005794 | Golgi apparatus |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0030424 | axon |
| CC | IDA | GO:0030496 | midbody |
| CC | IEA | GO:0032991 | protein-containing complex |
| CC | IEA | GO:0043025 | neuronal cell body |
| CC | IEA | GO:0043209 | myelin sheath |
Gene expression in normal tissue: GDI1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GDI1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194840 | Rho GTPase cycle |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs |
| reactome | R-HSA-9007101 | Rab regulation of trafficking |
| pid | p38alphabetadownstreampathway | Signaling mediated by p38-alpha and p38-beta |
| wikipathways | WP1984 | Integrated Breast Cancer Pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GDI1
CLASSFICATION
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