Summary: GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific cognitive disability. [provided by RefSeq, Jul 2008].

GDP dissociation inhibitor 1MIM:300104Ensembl:ENSG00000203879HGNC:HGNC:4226PA28641Xq28

GO terms in GDI1

Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0005092GDP-dissociation inhibitor activity
MFISSGO:0005093Rab GDP-dissociation inhibitor activity
MFIEAGO:0005096GTPase activator activity
MFIPIGO:0005515protein binding
MFIEAGO:0017137Rab GTPase binding
BPTASGO:0007165signal transduction
BPIEAGO:0015031protein transport
BPISSGO:0032482Rab protein signal transduction
BPIEAGO:0043547positive regulation of GTPase activity
BPIEAGO:0045773positive regulation of axon extension
BPISSGO:0050771negative regulation of axonogenesis
BPTASGO:0051056regulation of small GTPase mediated signal transduction
BPIEAGO:0051592response to calcium ion
BPIMPGO:0090315negative regulation of protein targeting to membrane
CCIEAGO:0005794Golgi apparatus
CCIEAGO:0032991protein-containing complex
CCIEAGO:0043025neuronal cell body
CCIEAGO:0043209myelin sheath

Gene expression in normal tissue: GDI1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GDI1

DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-194840Rho GTPase cycle
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-8876198RAB GEFs exchange GTP for GDP on RABs
reactomeR-HSA-9007101Rab regulation of trafficking
pidp38alphabetadownstreampathwaySignaling mediated by p38-alpha and p38-beta
wikipathwaysWP1984Integrated Breast Cancer Pathway

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GDI1