GNB5


Summary: Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternatively spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
G protein subunit beta 5MIM:604447Ensembl:ENSG00000069966HGNC:HGNC:4401PA2878015q21.2

Gene Categories:

TRANSPORTERION CHANNEL

GO terms in GNB5


Term TypeEvidence TypeGO Term IDGO Des.
MFNASGO:0003924GTPase activity
MFIDAGO:0005096GTPase activator activity
MFIDAGO:0005096GTPase activator activity
MFIPIGO:0005515protein binding
MFIPIGO:0031682G-protein gamma-subunit binding
MFIPIGO:0051087chaperone binding
CCIEAGO:0001750photoreceptor outer segment
CCIEAGO:0001917photoreceptor inner segment
CCIEAGO:0005634nucleus
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIEAGO:0005886plasma membrane
CCIEAGO:0043209myelin sheath
CCTASGO:1902773GTPase activator complex
BPTASGO:0006457protein folding
BPNASGO:0007165signal transduction
BPIDAGO:0007212dopamine receptor signaling pathway
BPIDAGO:0043547positive regulation of GTPase activity
BPIDAGO:1901386negative regulation of voltage-gated calcium channel activity

Gene expression in normal tissue: GNB5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GNB5


DatabasePathway IDPathway Des.
wikipathwaysWP2197Endothelin Pathways
wikipathwaysWP2355Corticotropin-releasing hormone signaling pathway
wikipathwaysWP289Myometrial Relaxation and Contraction Pathways
wikipathwaysWP35G Protein Signaling Pathways
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4223Ras Signaling
wikipathwaysWP536Calcium Regulation in the Cardiac Cell
pidcone_pathwayVisual signal transduction: Cones
pidrhodopsin_pathwayVisual signal transduction: Rods
pidtxa2pathwayThromboxane A2 receptor signaling
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04371Apelin signaling pathway - Homo sapiens (human)
kegghsa04713Circadian entrainment - Homo sapiens (human)
kegghsa04723Retrograde endocannabinoid signaling - Homo sapiens (human)
kegghsa04724Glutamatergic synapse - Homo sapiens (human)
kegghsa04725Cholinergic synapse - Homo sapiens (human)
kegghsa04726Serotonergic synapse - Homo sapiens (human)
kegghsa04727GABAergic synapse - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa05032Morphine addiction - Homo sapiens (human)
kegghsa05034Alcoholism - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
netpathPathway_CRHCRH
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-111885Opioid Signalling
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-202040G-protein activation
reactomeR-HSA-2187338Visual phototransduction
reactomeR-HSA-2187338Visual phototransduction
reactomeR-HSA-2514856The phototransduction cascade
reactomeR-HSA-2514856The phototransduction cascade
reactomeR-HSA-2514859Inactivation, recovery and regulation of the phototransduction cascade
reactomeR-HSA-2514859Inactivation, recovery and regulation of the phototransduction cascade
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373080Class B/2 (Secretin family receptors)
reactomeR-HSA-381676Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
reactomeR-HSA-381676Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-3858494Beta-catenin independent WNT signaling
reactomeR-HSA-3858494Beta-catenin independent WNT signaling
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-390466Chaperonin-mediated protein folding
reactomeR-HSA-391251Protein folding
reactomeR-HSA-392170ADP signalling through P2Y purinoceptor 12
reactomeR-HSA-392451G beta:gamma signalling through PI3Kgamma
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-392518Signal amplification
reactomeR-HSA-392518Signal amplification
reactomeR-HSA-392851Prostacyclin signalling through prostacyclin receptor
reactomeR-HSA-392851Prostacyclin signalling through prostacyclin receptor
reactomeR-HSA-397795G-protein beta:gamma signalling
reactomeR-HSA-400042Adrenaline,noradrenaline inhibits insulin secretion
reactomeR-HSA-400042Adrenaline,noradrenaline inhibits insulin secretion
reactomeR-HSA-4086398Ca2+ pathway
reactomeR-HSA-4086398Ca2+ pathway
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-416482G alpha (12/13) signalling events
reactomeR-HSA-418217G beta:gamma signalling through PLC beta
reactomeR-HSA-418346Platelet homeostasis
reactomeR-HSA-418346Platelet homeostasis
reactomeR-HSA-418555G alpha (s) signalling events
reactomeR-HSA-418592ADP signalling through P2Y purinoceptor 1
reactomeR-HSA-418592ADP signalling through P2Y purinoceptor 1
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-418597G alpha (z) signalling events
reactomeR-HSA-420092Glucagon-type ligand receptors
reactomeR-HSA-422356Regulation of insulin secretion
reactomeR-HSA-422356Regulation of insulin secretion
reactomeR-HSA-428930Thromboxane signalling through TP receptor
reactomeR-HSA-432040Vasopressin regulates renal water homeostasis via Aquaporins
reactomeR-HSA-445717Aquaporin-mediated transport
reactomeR-HSA-451326Activation of kainate receptors upon glutamate binding
reactomeR-HSA-456926Thrombin signalling through proteinase activated receptors (PARs)
reactomeR-HSA-456926Thrombin signalling through proteinase activated receptors (PARs)
reactomeR-HSA-500657Presynaptic function of Kainate receptors
reactomeR-HSA-500792GPCR ligand binding
reactomeR-HSA-6814122Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-76002Platelet activation, signaling and aggregation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GNB5

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