HAL
Summary: Histidine ammonia-lyase is a cytosolic enzyme catalyzing the first reaction in histidine catabolism, the nonoxidative deamination of L-histidine to trans-urocanic acid. Histidine ammonia-lyase defects cause histidinemia which is characterized by increased histidine and histamine and decreased urocanic acid in body fluids. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| histidine ammonia-lyase | MIM:609457 | Ensembl:ENSG00000084110 | HGNC:HGNC:4806 | PA29181 | 12q23.1 |
GO terms in HAL
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | EXP | GO:0004397 | histidine ammonia-lyase activity |
| MF | IBA | GO:0004397 | histidine ammonia-lyase activity |
| MF | IBA | GO:0016841 | ammonia-lyase activity |
| CC | TAS | GO:0005829 | cytosol |
| BP | IBA | GO:0006548 | histidine catabolic process |
| BP | TAS | GO:0006548 | histidine catabolic process |
| BP | IEA | GO:0019556 | histidine catabolic process to glutamate and formamide |
| BP | IEA | GO:0019557 | histidine catabolic process to glutamate and formate |
Gene expression in normal tissue: HAL
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HAL
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3925 | Amino Acid metabolism |
| smpdb | SMP00009 | Ammonia Recycling |
| smpdb | SMP00044 | Histidine Metabolism |
| smpdb | SMP00191 | Histidinemia |
| kegg | hsa00340 | Histidine metabolism - Homo sapiens (human) |
| humancyc | PWY-5030 | histidine degradation |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-6788656 | Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism |
| reactome | R-HSA-70921 | Histidine catabolism |
| reactome | R-HSA-71291 | Metabolism of amino acids and derivatives |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HAL
CLASSFICATION
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