HDAC8
Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| histone deacetylase 8 | MIM:300269 | Ensembl:ENSG00000147099 | HGNC:HGNC:13315 | PA37766 | Xq13.1 |
GO terms in HDAC8
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003682 | chromatin binding |
| MF | TAS | GO:0004407 | histone deacetylase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008134 | transcription factor binding |
| MF | IPI | GO:0030544 | Hsp70 protein binding |
| MF | IEA | GO:0032041 | NAD-dependent histone deacetylase activity (H3-K14 specific) |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IPI | GO:0051879 | Hsp90 protein binding |
| CC | TAS | GO:0000118 | histone deacetylase complex |
| CC | TAS | GO:0000228 | nuclear chromosome |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| BP | TAS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0006325 | chromatin organization |
| BP | TAS | GO:0006333 | chromatin assembly or disassembly |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IMP | GO:0007062 | sister chromatid cohesion |
| BP | IDA | GO:0031397 | negative regulation of protein ubiquitination |
| BP | IDA | GO:0031647 | regulation of protein stability |
| BP | IMP | GO:0032204 | regulation of telomere maintenance |
| BP | IEA | GO:0035984 | cellular response to trichostatin A |
| BP | IEA | GO:0045668 | negative regulation of osteoblast differentiation |
| BP | IEA | GO:0070932 | histone H3 deacetylation |
| BP | IMP | GO:0071922 | regulation of cohesin loading |
| BP | IEA | GO:1904322 | cellular response to forskolin |
| BP | IEA | GO:2000616 | negative regulation of histone H3-K9 acetylation |
Gene expression in normal tissue: HDAC8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HDAC8
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1980143 | Signaling by NOTCH1 |
| reactome | R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription |
| reactome | R-HSA-2467813 | Separation of Sister Chromatids |
| reactome | R-HSA-2500257 | Resolution of Sister Chromatid Cohesion |
| reactome | R-HSA-2555396 | Mitotic Metaphase and Anaphase |
| reactome | R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| reactome | R-HSA-2644603 | Signaling by NOTCH1 in Cancer |
| reactome | R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| reactome | R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| reactome | R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| reactome | R-HSA-3214815 | HDACs deacetylate histones |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-4839726 | Chromatin organization |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68882 | Mitotic Anaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP2064 | Neural Crest Differentiation |
| wikipathways | WP3414 | Initiation of transcription and translation elongation at the HIV-1 LTR |
| wikipathways | WP3996 | Ethanol effects on histone modifications |
| kegg | hsa05034 | Alcoholism - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| pid | hdac_classi_pathway | Signaling events mediated by HDAC Class I |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD318 | PAC-1 | 8 |
| iGMDRD150 | RITA | 6 |
| iGMDRD505 | Pevonedistat | 9 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD341 | Triacsin c | 10 |
| iGMDRD872 | BRD7137 | 1 |
| iGMDRD474 | Avrainvillamide | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HDAC8
CLASSFICATION
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