HDLBP
Summary: The protein encoded by this gene binds high density lipoprotein (HDL) and may function to regulate excess cholesterol levels in cells. The encoded protein also binds RNA and can induce heterochromatin formation. [provided by RefSeq, Mar 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| high density lipoprotein binding protein | MIM:142695 | Ensembl:ENSG00000115677 | HGNC:HGNC:4857 | PA29235 | 2q37.3 |
GO terms in HDLBP
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008289 | lipid binding |
| MF | HDA | GO:0045296 | cadherin binding |
| CC | IEA | GO:0005634 | nucleus |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0034364 | high-density lipoprotein particle |
| BP | IEA | GO:0006869 | lipid transport |
| BP | IEA | GO:0008203 | cholesterol metabolic process |
| BP | TAS | GO:0034384 | high-density lipoprotein particle clearance |
Gene expression in normal tissue: HDLBP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HDLBP
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-8964011 | HDL clearance |
| reactome | R-HSA-8964043 | Plasma lipoprotein clearance |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD405 | PIK-75 | 1 |
| iGMDRD116 | CD437 | 5 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD499 | PDMP | 3 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD552 | AZD-1775 | 3 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD484 | Pluripotin | 6 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD1008 | SR-II-138A | 1 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD885 | Compound 110 | 4 |
| iGMDRD441 | TW 37 | 5 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD802 | 4-methylfasudil | 2 |
| iGMDRD138 | PX 12 | 1 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD23 | Gossypol | 6 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD74 | Idarubicin | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HDLBP
CLASSFICATION
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