HMGA1


Summary: This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes. [provided by RefSeq, Jan 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
high mobility group AT-hook 1MIM:600701Ensembl:ENSG00000137309HGNC:HGNC:5010PA350946p21.31

GO terms in HMGA1


Term TypeEvidence TypeGO Term IDGO Des.
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIDAGO:0001158enhancer sequence-specific DNA binding
MFISSGO:0001205transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding
MFTASGO:0003677DNA binding
MFIDAGO:0003680AT DNA binding
MFISSGO:0003680AT DNA binding
MFTASGO:0003680AT DNA binding
MFISSGO:0003682chromatin binding
MFIBAGO:0003700DNA-binding transcription factor activity
MFIBAGO:0003906DNA-(apurinic or apyrimidinic site) endonuclease activity
MFIPIGO:0005515protein binding
MFIDAGO:0008134transcription factor binding
MFIPIGO:0019899enzyme binding
MFIMPGO:0030374nuclear receptor transcription coactivator activity
MFIDAGO:0042974retinoic acid receptor binding
MFIDAGO:0042975peroxisome proliferator activated receptor binding
MFIDAGO:0046965retinoid X receptor binding
CCHDAGO:0005634nucleus
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCTASGO:0005667transcription factor complex
CCTASGO:0005829cytosol
CCHDAGO:0005925focal adhesion
CCIDAGO:0035985senescence-associated heterochromatin focus
CCISSGO:0090575RNA polymerase II transcription factor complex
BPNASGO:0006268DNA unwinding involved in DNA replication
BPIBAGO:0006284base-excision repair
BPTASGO:0006337nucleosome disassembly
BPIBAGO:0006355regulation of transcription, DNA-templated
BPTASGO:0006355regulation of transcription, DNA-templated
BPIEAGO:0006366transcription by RNA polymerase II
BPIMPGO:0008285negative regulation of cell proliferation
BPIEPGO:0009615response to virus
BPTASGO:0031936negative regulation of chromatin silencing
BPIDAGO:0035986senescence-associated heterochromatin focus assembly
BPIMPGO:0045892negative regulation of transcription, DNA-templated
BPIMPGO:0045893positive regulation of transcription, DNA-templated
BPISSGO:0045944positive regulation of transcription by RNA polymerase II
BPTASGO:0051169nuclear transport
BPTASGO:0065003protein-containing complex assembly
BPTASGO:0075713establishment of integrated proviral latency
BPIDAGO:0090402oncogene-induced cell senescence
BPIMPGO:2000774positive regulation of cellular senescence

Gene expression in normal tissue: HMGA1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HMGA1


DatabasePathway IDPathway Des.
wikipathwaysWP2003miR-targeted genes in leukocytes - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2006miR-targeted genes in squamous cell - TarBase
wikipathwaysWP236Adipogenesis
wikipathwaysWP3527Preimplantation Embryo
wikipathwaysWP615Senescence and Autophagy in Cancer
pidil4_2pathwayIL4-mediated signaling events
pidmyc_activpathwayValidated targets of C-MYC transcriptional activation
biocartail4pathwayil 4 signaling pathway
reactomeR-HSA-162587HIV Life Cycle
reactomeR-HSA-162592Integration of provirus
reactomeR-HSA-162594Early Phase of HIV Life Cycle
reactomeR-HSA-162906HIV Infection
reactomeR-HSA-162909Host Interactions of HIV factors
reactomeR-HSA-1643685Disease
reactomeR-HSA-1648432-LTR circle formation
reactomeR-HSA-175567Integration of viral DNA into host genomic DNA
reactomeR-HSA-176033Interactions of Vpr with host cellular proteins
reactomeR-HSA-177539Autointegration results in viral DNA circles
reactomeR-HSA-180689APOBEC3G mediated resistance to HIV-1 infection
reactomeR-HSA-180910Vpr-mediated nuclear import of PICs
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-2559584Formation of Senescence-Associated Heterochromatin Foci (SAHF)
reactomeR-HSA-2559586DNA Damage/Telomere Stress Induced Senescence
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-8953897Cellular responses to external stimuli

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD137Indisulam3
iGMDRD427ABT7373
iGMDRD297Austocystin D3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HMGA1

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