HMGA1
Summary: This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes. [provided by RefSeq, Jan 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| high mobility group AT-hook 1 | MIM:600701 | Ensembl:ENSG00000137309 | HGNC:HGNC:5010 | PA35094 | 6p21.31 |
GO terms in HMGA1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0001158 | enhancer sequence-specific DNA binding |
| MF | ISS | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding |
| MF | TAS | GO:0003677 | DNA binding |
| MF | IDA | GO:0003680 | AT DNA binding |
| MF | ISS | GO:0003680 | AT DNA binding |
| MF | TAS | GO:0003680 | AT DNA binding |
| MF | ISS | GO:0003682 | chromatin binding |
| MF | IBA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IBA | GO:0003906 | DNA-(apurinic or apyrimidinic site) endonuclease activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008134 | transcription factor binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IMP | GO:0030374 | nuclear receptor transcription coactivator activity |
| MF | IDA | GO:0042974 | retinoic acid receptor binding |
| MF | IDA | GO:0042975 | peroxisome proliferator activated receptor binding |
| MF | IDA | GO:0046965 | retinoid X receptor binding |
| CC | HDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005667 | transcription factor complex |
| CC | TAS | GO:0005829 | cytosol |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0035985 | senescence-associated heterochromatin focus |
| CC | ISS | GO:0090575 | RNA polymerase II transcription factor complex |
| BP | NAS | GO:0006268 | DNA unwinding involved in DNA replication |
| BP | IBA | GO:0006284 | base-excision repair |
| BP | TAS | GO:0006337 | nucleosome disassembly |
| BP | IBA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | TAS | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IMP | GO:0008285 | negative regulation of cell proliferation |
| BP | IEP | GO:0009615 | response to virus |
| BP | TAS | GO:0031936 | negative regulation of chromatin silencing |
| BP | IDA | GO:0035986 | senescence-associated heterochromatin focus assembly |
| BP | IMP | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IMP | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | ISS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0051169 | nuclear transport |
| BP | TAS | GO:0065003 | protein-containing complex assembly |
| BP | TAS | GO:0075713 | establishment of integrated proviral latency |
| BP | IDA | GO:0090402 | oncogene-induced cell senescence |
| BP | IMP | GO:2000774 | positive regulation of cellular senescence |
Gene expression in normal tissue: HMGA1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HMGA1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2003 | miR-targeted genes in leukocytes - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2006 | miR-targeted genes in squamous cell - TarBase |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP3527 | Preimplantation Embryo |
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
| pid | il4_2pathway | IL4-mediated signaling events |
| pid | myc_activpathway | Validated targets of C-MYC transcriptional activation |
| biocarta | il4pathway | il 4 signaling pathway |
| reactome | R-HSA-162587 | HIV Life Cycle |
| reactome | R-HSA-162592 | Integration of provirus |
| reactome | R-HSA-162594 | Early Phase of HIV Life Cycle |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-162909 | Host Interactions of HIV factors |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-164843 | 2-LTR circle formation |
| reactome | R-HSA-175567 | Integration of viral DNA into host genomic DNA |
| reactome | R-HSA-176033 | Interactions of Vpr with host cellular proteins |
| reactome | R-HSA-177539 | Autointegration results in viral DNA circles |
| reactome | R-HSA-180689 | APOBEC3G mediated resistance to HIV-1 infection |
| reactome | R-HSA-180910 | Vpr-mediated nuclear import of PICs |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) |
| reactome | R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD137 | Indisulam | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD297 | Austocystin D | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HMGA1
CLASSFICATION
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