HSPH1
Summary: This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers. [provided by RefSeq, Mar 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| heat shock protein family H (Hsp110) member 1 | MIM:610703 | Ensembl:ENSG00000120694 | HGNC:HGNC:16969 | PA134869917 | 13q12.3 |
GO terms in HSPH1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000774 | adenyl-nucleotide exchange factor activity |
| MF | TAS | GO:0000774 | adenyl-nucleotide exchange factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0043014 | alpha-tubulin binding |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005874 | microtubule |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | TAS | GO:0071682 | endocytic vesicle lumen |
| BP | TAS | GO:0006898 | receptor-mediated endocytosis |
| BP | TAS | GO:0006986 | response to unfolded protein |
| BP | TAS | GO:0045345 | positive regulation of MHC class I biosynthetic process |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0051085 | chaperone cofactor-dependent protein refolding |
| BP | TAS | GO:0051135 | positive regulation of NK T cell activation |
| BP | IEA | GO:0061098 | positive regulation of protein tyrosine kinase activity |
| BP | TAS | GO:1900034 | regulation of cellular response to heat |
| BP | IEA | GO:1903748 | negative regulation of establishment of protein localization to mitochondrion |
| BP | IEA | GO:1903751 | negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide |
| BP | IEA | GO:1903753 | negative regulation of p38MAPK cascade |
Gene expression in normal tissue: HSPH1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HSPH1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| wikipathways | WP3395 | Cellular response to heat stress |
| reactome | R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors |
| reactome | R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-3000484 | Scavenging by Class F Receptors |
| reactome | R-HSA-3000484 | Scavenging by Class F Receptors |
| reactome | R-HSA-3371453 | Regulation of HSF1-mediated heat shock response |
| reactome | R-HSA-3371556 | Cellular response to heat stress |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD368 | Oxaliplatin | 1 |
| iGMDRD21 | Fluorouracil | 2 |
| iGMDRD160 | Cis-Platin | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HSPH1
CLASSFICATION
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