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Summary: Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
intestinal cell kinase	MIM:612325	Ensembl:ENSG00000112144	HGNC:HGNC:21219	PA134894544	6p12.1

Gene Categories:

DRUGGABLE GENOME SERINE THREONINE KINASE KINASE

GO terms in ICK

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IDA	GO:0000287	magnesium ion binding
MF	IBA	GO:0004674	protein serine/threonine kinase activity
MF	IDA	GO:0004674	protein serine/threonine kinase activity
MF	IPI	GO:0005515	protein binding
MF	IDA	GO:0005524	ATP binding
BP	IDA	GO:0006468	protein phosphorylation
BP	TAS	GO:0007165	signal transduction
BP	IEA	GO:0007275	multicellular organism development
BP	IBA	GO:0010468	regulation of gene expression
BP	IBA	GO:0035556	intracellular signal transduction
BP	IDA	GO:0035556	intracellular signal transduction
BP	ISS	GO:0035720	intraciliary anterograde transport
BP	ISS	GO:0035721	intraciliary retrograde transport
BP	IBA	GO:0042073	intraciliary transport
BP	ISS	GO:0042073	intraciliary transport
BP	IBA	GO:0060271	cilium assembly
BP	IMP	GO:0060271	cilium assembly
CC	IDA	GO:0001650	fibrillar center
CC	IBA	GO:0005634	nucleus
CC	ISS	GO:0005634	nucleus
CC	IBA	GO:0005737	cytoplasm
CC	IEA	GO:0005829	cytosol
CC	IBA	GO:0005929	cilium
CC	ISS	GO:0005929	cilium
CC	ISS	GO:0036064	ciliary basal body
CC	IMP	GO:0097542	ciliary tip
CC	ISS	GO:0097546	ciliary base

Gene expression in normal tissue: ICK

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ICK

Database	Pathway ID	Pathway Des.

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD356	PNU-74654	2
iGMDRD23	Gossypol	2
iGMDRD524	ISX-9	6
iGMDRD690	PRIMA-1MET	2
iGMDRD60	Quinoclamine	2
iGMDRD888	Compound 44	3
iGMDRD506	Fedratinib	2
iGMDRD562	Navitoclax	3
iGMDRD399	Selumetinib	2
iGMDRD887	Compound 23 citrate	2
iGMDRD885	Compound 110	4
iGMDRD226	ML006	4
iGMDRD187	BRD9876	2
iGMDRD270	Ciclosporin	2
iGMDRD474	Avrainvillamide	2
iGMDRD634	SCHEMBL2608041	3
iGMDRD375	GW-405833	2
iGMDRD297	Austocystin D	2
iGMDRD484	Pluripotin	3
iGMDRD781	Sirolimus	2
iGMDRD546	BMS-754807	4
iGMDRD427	ABT737	2
iGMDRD889	Compound 7d-cis	2
iGMDRD1008	SR-II-138A	4
iGMDRD82	Quiflapon	2
iGMDRD329	Merck60	2
iGMDRD872	BRD7137	2
iGMDRD481	Dactolisib	2
iGMDRD267	Oligomycin A	2
iGMDRD434	BMS-536924	2
iGMDRD103	SN-38	3
iGMDRD137	Indisulam	3
iGMDRD945	ML214	1
iGMDRD154	NSC23766	6
iGMDRD177	Teniposide	1
iGMDRD123	Isoevodiamine	3
iGMDRD57	Chloropentafluorobenzene	2
iGMDRD219	Bax channel blocker	3
iGMDRD523	Cyanoquinoline, 11	2
iGMDRD148	Pifithrin-mu	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ICK

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.