IFNB1
Summary: This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. [provided by RefSeq, Sep 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| interferon beta 1 | MIM:147640 | Ensembl:ENSG00000171855 | HGNC:HGNC:5434 | PA29672 | 9p21.3 |
Gene Categories:
DRUGGABLE GENOMEGO terms in IFNB1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005125 | cytokine activity |
| MF | IDA | GO:0005125 | cytokine activity |
| MF | IBA | GO:0005132 | type I interferon receptor binding |
| MF | NAS | GO:0005132 | type I interferon receptor binding |
| MF | IMP | GO:0008811 | chloramphenicol O-acetyltransferase activity |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| BP | IBA | GO:0002250 | adaptive immune response |
| BP | IBA | GO:0002286 | T cell activation involved in immune response |
| BP | IMP | GO:0002312 | B cell activation involved in immune response |
| BP | IBA | GO:0002323 | natural killer cell activation involved in immune response |
| BP | IBA | GO:0006959 | humoral immune response |
| BP | TAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | TAS | GO:0007596 | blood coagulation |
| BP | NAS | GO:0009615 | response to virus |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IBA | GO:0019221 | cytokine-mediated signaling pathway |
| BP | NAS | GO:0030101 | natural killer cell activation |
| BP | IBA | GO:0030183 | B cell differentiation |
| BP | IBA | GO:0033141 | positive regulation of peptidyl-serine phosphorylation of STAT protein |
| BP | IDA | GO:0033141 | positive regulation of peptidyl-serine phosphorylation of STAT protein |
| BP | IDA | GO:0035458 | cellular response to interferon-beta |
| BP | IBA | GO:0042100 | B cell proliferation |
| BP | NAS | GO:0042100 | B cell proliferation |
| BP | IBA | GO:0043330 | response to exogenous dsRNA |
| BP | IDA | GO:0043330 | response to exogenous dsRNA |
| BP | IDA | GO:0045071 | negative regulation of viral genome replication |
| BP | NAS | GO:0045089 | positive regulation of innate immune response |
| BP | NAS | GO:0045343 | regulation of MHC class I biosynthetic process |
| BP | IDA | GO:0045581 | negative regulation of T cell differentiation |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0051607 | defense response to virus |
| BP | IDA | GO:0060337 | type I interferon signaling pathway |
| BP | TAS | GO:0060337 | type I interferon signaling pathway |
| BP | TAS | GO:0071360 | cellular response to exogenous dsRNA |
| BP | IDA | GO:2000552 | negative regulation of T-helper 2 cell cytokine production |
| BP | IDA | GO:2001235 | positive regulation of apoptotic signaling pathway |
Gene expression in normal tissue: IFNB1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IFNB1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP12 | Osteoclast Signaling |
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP262 | EBV LMP1 signaling |
| wikipathways | WP3851 | TLR4 Signaling and Tolerance |
| wikipathways | WP3865 | RIG-I-like Receptor Signaling |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4136 | Fibrin Complement Receptor 3 Signaling Pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP530 | Cytokines and Inflammatory Response |
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
| wikipathways | WP619 | Type II interferon signaling (IFNG) |
| wikipathways | WP75 | Toll-like Receptor Signaling Pathway |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04622 | RIG-I-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04623 | Cytosolic DNA-sensing pathway - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| kegg | hsa05142 | Chagas disease (American trypanosomiasis) - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| pid | smad2_3nuclearpathway | Regulation of nuclear SMAD2/3 signaling |
| biocarta | ifnapathway | ifn alpha signaling pathway |
| biocarta | il1rpathway | signal transduction through il1r |
| biocarta | pcafpathway | the information processing pathway at the ifn beta enhancer |
| biocarta | ranklpathway | bone remodeling |
| biocarta | rnapathway | double stranded rna induced gene expression |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2559580 | Oxidative Stress Induced Senescence |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-909733 | Interferon alpha/beta signaling |
| reactome | R-HSA-909733 | Interferon alpha/beta signaling |
| reactome | R-HSA-912694 | Regulation of IFNA signaling |
| reactome | R-HSA-912694 | Regulation of IFNA signaling |
| reactome | R-HSA-913531 | Interferon Signaling |
| reactome | R-HSA-913531 | Interferon Signaling |
| reactome | R-HSA-918233 | TRAF3-dependent IRF activation pathway |
| reactome | R-HSA-933541 | TRAF6 mediated IRF7 activation |
| reactome | R-HSA-983231 | Factors involved in megakaryocyte development and platelet production |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD210 | AC55649 | 3 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD484 | Pluripotin | 9 |
| iGMDRD414 | MST-312 | 6 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD269 | Purmorphamine | 2 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD154 | NSC23766 | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IFNB1
CLASSFICATION
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