ILF3


Summary: This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
interleukin enhancer binding factor 3MIM:603182Ensembl:ENSG00000129351HGNC:HGNC:6038PA2985319p13.2

GO terms in ILF3


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0006351transcription, DNA-templated
BPIDAGO:0006468protein phosphorylation
BPISSGO:0017148negative regulation of translation
BPISSGO:0045071negative regulation of viral genome replication
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIEAGO:0051607defense response to virus
CCHDAGO:0005576extracellular region
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCNASGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIDAGO:0005730nucleolus
CCIDAGO:0005737cytoplasm
CCIDAGO:0005739mitochondrion
CCHDAGO:0016020membrane
CCIDAGO:1990904ribonucleoprotein complex
MFIDAGO:0003677DNA binding
MFHDAGO:0003723RNA binding
MFNASGO:0003723RNA binding
MFIBAGO:0003725double-stranded RNA binding
MFIDAGO:0003725double-stranded RNA binding
MFIBAGO:0003727single-stranded RNA binding
MFIPIGO:0005515protein binding

Gene expression in normal tissue: ILF3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ILF3


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ILF3

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