ILF3
Summary: This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| interleukin enhancer binding factor 3 | MIM:603182 | Ensembl:ENSG00000129351 | HGNC:HGNC:6038 | PA29853 | 19p13.2 |
GO terms in ILF3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | ISS | GO:0017148 | negative regulation of translation |
| BP | ISS | GO:0045071 | negative regulation of viral genome replication |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IEA | GO:0051607 | defense response to virus |
| CC | HDA | GO:0005576 | extracellular region |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | NAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:1990904 | ribonucleoprotein complex |
| MF | IDA | GO:0003677 | DNA binding |
| MF | HDA | GO:0003723 | RNA binding |
| MF | NAS | GO:0003723 | RNA binding |
| MF | IBA | GO:0003725 | double-stranded RNA binding |
| MF | IDA | GO:0003725 | double-stranded RNA binding |
| MF | IBA | GO:0003727 | single-stranded RNA binding |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: ILF3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ILF3
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ILF3
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