ING1


Summary: This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
inhibitor of growth family member 1MIM:601566Ensembl:ENSG00000153487HGNC:HGNC:6062PA2987213q34

GO terms in ING1


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIDAGO:0035064methylated histone binding
MFIEAGO:0046872metal ion binding
CCNASGO:0005634nucleus
BPIEAGO:0007049cell cycle
BPIEAGO:0008285negative regulation of cell proliferation
BPIEAGO:0010941regulation of cell death
BPNASGO:0030308negative regulation of cell growth

Gene expression in normal tissue: ING1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ING1


DatabasePathway IDPathway Des.
wikipathwaysWP615Senescence and Autophagy in Cancer

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD42Vorinostat6
iGMDRD60Quinoclamine2
iGMDRD886Compound 1541A2
iGMDRD329Merck606
iGMDRD367Ro 28-16752
iGMDRD231Importazole3
iGMDRD77Itraconazole2
iGMDRD318PAC-13
iGMDRD226ML0062
iGMDRD634SCHEMBL26080414
iGMDRD123Isoevodiamine3
iGMDRD466Chaetocin2
iGMDRD57Chloropentafluorobenzene2
iGMDRD85Ursolic acid2
iGMDRD71Sparfosic acid3
iGMDRD427ABT7373
iGMDRD116CD4373
iGMDRD560MK-22064
iGMDRD420Leucascandrolide A1
iGMDRD512nutlin 31
iGMDRD229B023

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ING1

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