INPP4A
Summary: This gene encodes an Mg++ independent enzyme that hydrolyzes the 4-position phosphate from the inositol ring of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Multiple transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| inositol polyphosphate-4-phosphatase type I A | MIM:600916 | Ensembl:ENSG00000040933 | HGNC:HGNC:6074 | PA29882 | 2q11.2 |
Gene Categories:
CLINICALLY ACTIONABLEGO terms in INPP4A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| BP | TAS | GO:0006661 | phosphatidylinositol biosynthetic process |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0016311 | dephosphorylation |
| BP | IEA | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process |
| BP | TAS | GO:0043647 | inositol phosphate metabolic process |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0016316 | phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity |
| MF | TAS | GO:0016316 | phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity |
| MF | TAS | GO:0017161 | inositol-1,3,4-trisphosphate 4-phosphatase activity |
| MF | IEA | GO:0034597 | phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity |
| MF | TAS | GO:0052828 | inositol-3,4-bisphosphate 4-phosphatase activity |
Gene expression in normal tissue: INPP4A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in INPP4A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1483249 | Inositol phosphate metabolism |
| reactome | R-HSA-1483255 | PI Metabolism |
| reactome | R-HSA-1483257 | Phospholipid metabolism |
| reactome | R-HSA-1660499 | Synthesis of PIPs at the plasma membrane |
| reactome | R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane |
| reactome | R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol |
| reactome | R-HSA-556833 | Metabolism of lipids |
| humancyc | PWY-6368 | 3-phosphoinositide degradation |
| kegg | hsa00562 | Inositol phosphate metabolism - Homo sapiens (human) |
| kegg | hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| wikipathways | WP481 | Insulin Signaling |
| smpdb | SMP00011 | Inositol Metabolism |
| smpdb | SMP00462 | Inositol Phosphate Metabolism |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD652 | UNC0638 | 1 |
| iGMDRD719 | IOX2 | 1 |
| iGMDRD432 | AT-7519 | 1 |
| iGMDRD1015 | THZ-2-102-1 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in INPP4A
CLASSFICATION
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