ITGB3
Summary: The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| integrin subunit beta 3 | MIM:173470 | Ensembl:ENSG00000259207 | HGNC:HGNC:6156 | PA205 | 17q21.32 |
GO terms in ITGB3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IBA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0005925 | focal adhesion |
| CC | IBA | GO:0008305 | integrin complex |
| CC | IDA | GO:0008305 | integrin complex |
| CC | HDA | GO:0009986 | cell surface |
| CC | IBA | GO:0009986 | cell surface |
| CC | IDA | GO:0009986 | cell surface |
| CC | TAS | GO:0031092 | platelet alpha granule membrane |
| CC | IDA | GO:0031258 | lamellipodium membrane |
| CC | IDA | GO:0031527 | filopodium membrane |
| CC | IDA | GO:0031528 | microvillus membrane |
| CC | IDA | GO:0032587 | ruffle membrane |
| CC | IDA | GO:0034683 | integrin alphav-beta3 complex |
| CC | IDA | GO:0035866 | alphav-beta3 integrin-PKCalpha complex |
| CC | IDA | GO:0035867 | alphav-beta3 integrin-IGF-1-IGF1R complex |
| CC | IDA | GO:0035868 | alphav-beta3 integrin-HMGB1 complex |
| CC | IDA | GO:0042470 | melanosome |
| CC | IDA | GO:0043235 | receptor complex |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | TAS | GO:0071062 | alphav-beta3 integrin-vitronectin complex |
| BP | TAS | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IMP | GO:0001938 | positive regulation of endothelial cell proliferation |
| BP | TAS | GO:0002576 | platelet degranulation |
| BP | TAS | GO:0007155 | cell adhesion |
| BP | IBA | GO:0007160 | cell-matrix adhesion |
| BP | IMP | GO:0007160 | cell-matrix adhesion |
| BP | HDA | GO:0007229 | integrin-mediated signaling pathway |
| BP | IBA | GO:0007229 | integrin-mediated signaling pathway |
| BP | TAS | GO:0007229 | integrin-mediated signaling pathway |
| BP | TAS | GO:0007596 | blood coagulation |
| BP | IMP | GO:0010595 | positive regulation of endothelial cell migration |
| BP | IMP | GO:0010745 | negative regulation of macrophage derived foam cell differentiation |
| BP | IMP | GO:0010888 | negative regulation of lipid storage |
| BP | IMP | GO:0014909 | smooth muscle cell migration |
| BP | IBA | GO:0016477 | cell migration |
| BP | IMP | GO:0030168 | platelet activation |
| BP | TAS | GO:0030198 | extracellular matrix organization |
| BP | TAS | GO:0030949 | positive regulation of vascular endothelial growth factor receptor signaling pathway |
| BP | IMP | GO:0031589 | cell-substrate adhesion |
| BP | IMP | GO:0032147 | activation of protein kinase activity |
| BP | IMP | GO:0032369 | negative regulation of lipid transport |
| BP | IBA | GO:0033627 | cell adhesion mediated by integrin |
| BP | IDA | GO:0033627 | cell adhesion mediated by integrin |
| BP | IMP | GO:0034113 | heterotypic cell-cell adhesion |
| BP | IDA | GO:0034446 | substrate adhesion-dependent cell spreading |
| BP | TAS | GO:0035295 | tube development |
| BP | IMP | GO:0038027 | apolipoprotein A-I-mediated signaling pathway |
| BP | IC | GO:0042060 | wound healing |
| BP | IGI | GO:0043277 | apoptotic cell clearance |
| BP | TAS | GO:0045124 | regulation of bone resorption |
| BP | IMP | GO:0045715 | negative regulation of low-density lipoprotein particle receptor biosynthetic process |
| BP | IMP | GO:0046718 | viral entry into host cell |
| BP | TAS | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | IEP | GO:0048333 | mesodermal cell differentiation |
| BP | IMP | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| BP | IMP | GO:0050748 | negative regulation of lipoprotein metabolic process |
| BP | TAS | GO:0050900 | leukocyte migration |
| BP | IMP | GO:0050919 | negative chemotaxis |
| BP | TAS | GO:0060055 | angiogenesis involved in wound healing |
| BP | IMP | GO:0070527 | platelet aggregation |
| MF | IEA | GO:0001618 | virus receptor activity |
| MF | IBA | GO:0001968 | fibronectin binding |
| MF | IMP | GO:0001968 | fibronectin binding |
| MF | IDA | GO:0002020 | protease binding |
| MF | IDA | GO:0003756 | protein disulfide isomerase activity |
| MF | TAS | GO:0005161 | platelet-derived growth factor receptor binding |
| MF | IBA | GO:0005178 | integrin binding |
| MF | IPI | GO:0005178 | integrin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0015026 | coreceptor activity |
| MF | IDA | GO:0017134 | fibroblast growth factor binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IDA | GO:0019960 | C-X3-C chemokine binding |
| MF | IDA | GO:0031994 | insulin-like growth factor I binding |
| MF | IDA | GO:0038132 | neuregulin binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IPI | GO:0043184 | vascular endothelial growth factor receptor 2 binding |
| MF | TAS | GO:0043184 | vascular endothelial growth factor receptor 2 binding |
| MF | IPI | GO:0050839 | cell adhesion molecule binding |
| MF | IDA | GO:0050840 | extracellular matrix binding |
| MF | IBA | GO:0070051 | fibrinogen binding |
Gene expression in normal tissue: ITGB3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ITGB3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_Fibroblast__growth__factor-1 | Fibroblast growth factor-1 |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04145 | Phagosome - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04512 | ECM-receptor interaction - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| kegg | hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05410 | Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human) |
| kegg | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human) |
| kegg | hsa05414 | Dilated cardiomyopathy (DCM) - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114608 | Platelet degranulation |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1566948 | Elastic fibre formation |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| reactome | R-HSA-210990 | PECAM1 interactions |
| reactome | R-HSA-2129379 | Molecules associated with elastic fibres |
| reactome | R-HSA-216083 | Integrin cell surface interactions |
| reactome | R-HSA-216083 | Integrin cell surface interactions |
| reactome | R-HSA-3000170 | Syndecan interactions |
| reactome | R-HSA-3000170 | Syndecan interactions |
| reactome | R-HSA-3000171 | Non-integrin membrane-ECM interactions |
| reactome | R-HSA-3000171 | Non-integrin membrane-ECM interactions |
| reactome | R-HSA-3000178 | ECM proteoglycans |
| reactome | R-HSA-354192 | Integrin alphaIIb beta3 signaling |
| reactome | R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins |
| reactome | R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-445144 | Signal transduction by L1 |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5674135 | MAP2K and MAPK activation |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants |
| reactome | R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants |
| reactome | R-HSA-6802949 | Signaling by RAS mutants |
| reactome | R-HSA-6802952 | Signaling by BRAF and RAF fusions |
| reactome | R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| reactome | R-HSA-6802957 | Oncogenic MAPK signaling |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ |
| reactome | R-HSA-76009 | Platelet Aggregation (Plug Formation) |
| reactome | R-HSA-9006921 | Integrin signaling |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| biocarta | edg1pathway | phospholipids as signalling intermediaries |
| pid | arf6_pathway | Arf6 signaling events |
| pid | avb3_integrin_pathway | Integrins in angiogenesis |
| pid | avb3_opn_pathway | Osteopontin-mediated events |
| pid | il4_2pathway | IL4-mediated signaling events |
| pid | integrin3_pathway | Beta3 integrin cell surface interactions |
| pid | nectin_pathway | Nectin adhesion pathway |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | ptp1bpathway | Signaling events mediated by PTP1B |
| pid | upa_upar_pathway | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| pid | vegfr1_2_pathway | Signaling events mediated by VEGFR1 and VEGFR2 |
| pharmgkb | PA154444041 | Platelet Aggregation Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA2032 | VEGF Signaling Pathway |
| wikipathways | WP12 | Osteoclast Signaling |
| wikipathways | WP1434 | Osteopontin Signaling |
| wikipathways | WP1455 | Serotonin Transporter Activity |
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP2118 | Arrhythmogenic Right Ventricular Cardiomyopathy |
| wikipathways | WP2572 | Primary Focal Segmental Glomerulosclerosis FSGS |
| wikipathways | WP2806 | Human Complement System |
| wikipathways | WP2849 | Hematopoietic Stem Cell Differentiation |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP322 | Osteoblast Signaling |
| wikipathways | WP3301 | MFAP5-mediated ovarian cancer cell motility and invasiveness |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4180 | Ebola Virus Pathway on Host |
| wikipathways | WP4217 | Ebola Virus Pathway on Host |
| wikipathways | WP727 | Monoamine Transport |
| smpdb | SMP00265 | Abciximab Action Pathway |
| smpdb | SMP00266 | Eptifibatide Action Pathway |
| smpdb | SMP00267 | Tirofiban Action Pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ITGB3
CLASSFICATION
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