ITPR2


Summary: The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
inositol 1,4,5-trisphosphate receptor type 2MIM:600144Ensembl:ENSG00000123104HGNC:HGNC:6181PA2997912p11.23

GO terms in ITPR2


Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0001666response to hypoxia
BPTASGO:0007165signal transduction
BPTASGO:0030168platelet activation
BPIEAGO:0048016inositol phosphate-mediated signaling
BPTASGO:0050796regulation of insulin secretion
BPIBAGO:0051209release of sequestered calcium ion into cytosol
BPISSGO:0051209release of sequestered calcium ion into cytosol
BPIEAGO:0071320cellular response to cAMP
BPIEAGO:0071361cellular response to ethanol
BPTASGO:1903779regulation of cardiac conduction
CCIDAGO:0005634nucleus
CCIDAGO:0005783endoplasmic reticulum
CCIBAGO:0005789endoplasmic reticulum membrane
CCTASGO:0005789endoplasmic reticulum membrane
CCIBAGO:0005886plasma membrane
CCIDAGO:0005886plasma membrane
CCIEAGO:0005938cell cortex
CCHDAGO:0016020membrane
CCIEAGO:0016021integral component of membrane
CCIBAGO:0016529sarcoplasmic reticulum
CCIBAGO:0030659cytoplasmic vesicle membrane
CCIBAGO:0030667secretory granule membrane
CCTASGO:0031095platelet dense tubular network membrane
CCIMPGO:0033017sarcoplasmic reticulum membrane
CCIDAGO:0043235receptor complex
MFIBAGO:0005220inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
MFISSGO:0005220inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
MFIBAGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
MFTASGO:0015085calcium ion transmembrane transporter activity
MFIBAGO:0035091phosphatidylinositol binding
MFIEAGO:0035091phosphatidylinositol binding
MFIBAGO:0070679inositol 1,4,5 trisphosphate binding
MFIEAGO:0070679inositol 1,4,5 trisphosphate binding
MFIPIGO:0097110scaffold protein binding

Gene expression in normal tissue: ITPR2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ITPR2


DatabasePathway IDPathway Des.
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-111885Opioid Signalling
reactomeR-HSA-112040G-protein mediated events
reactomeR-HSA-112043PLC beta mediated events
reactomeR-HSA-114508Effects of PIP2 hydrolysis
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-139853Elevation of cytosolic Ca2+ levels
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1489509DAG and IP3 signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosis
reactomeR-HSA-2029485Role of phospholipids in phagocytosis
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2871809FCERI mediated Ca+2 mobilization
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-381676Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
reactomeR-HSA-3858494Beta-catenin independent WNT signaling
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-397014Muscle contraction
reactomeR-HSA-397014Muscle contraction
reactomeR-HSA-4086398Ca2+ pathway
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-418346Platelet homeostasis
reactomeR-HSA-418360Platelet calcium homeostasis
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-422356Regulation of insulin secretion
reactomeR-HSA-422356Regulation of insulin secretion
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-5218921VEGFR2 mediated cell proliferation
reactomeR-HSA-5576891Cardiac conduction
reactomeR-HSA-5576891Cardiac conduction
reactomeR-HSA-5578775Ion homeostasis
reactomeR-HSA-5578775Ion homeostasis
reactomeR-HSA-5607763CLEC7A (Dectin-1) induces NFAT activation
reactomeR-HSA-5607764CLEC7A (Dectin-1) signaling
reactomeR-HSA-5621481C-type lectin receptors (CLRs)
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-983695Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
reactomeR-HSA-983695Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
reactomeR-HSA-983705Signaling by the B Cell Receptor (BCR)
reactomeR-HSA-983705Signaling by the B Cell Receptor (BCR)
wikipathwaysWP2059Alzheimers Disease
wikipathwaysWP289Myometrial Relaxation and Contraction Pathways
wikipathwaysWP536Calcium Regulation in the Cardiac Cell
netpathPathway_BCRBCR
kegghsa04020Calcium signaling pathway - Homo sapiens (human)
kegghsa04022cGMP-PKG signaling pathway - Homo sapiens (human)
kegghsa04070Phosphatidylinositol signaling system - Homo sapiens (human)
kegghsa04114Oocyte meiosis - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04270Vascular smooth muscle contraction - Homo sapiens (human)
kegghsa04371Apelin signaling pathway - Homo sapiens (human)
kegghsa04540Gap junction - Homo sapiens (human)
kegghsa04611Platelet activation - Homo sapiens (human)
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
kegghsa04625C-type lectin receptor signaling pathway - Homo sapiens (human)
kegghsa04720Long-term potentiation - Homo sapiens (human)
kegghsa04723Retrograde endocannabinoid signaling - Homo sapiens (human)
kegghsa04724Glutamatergic synapse - Homo sapiens (human)
kegghsa04725Cholinergic synapse - Homo sapiens (human)
kegghsa04726Serotonergic synapse - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
kegghsa04730Long-term depression - Homo sapiens (human)
kegghsa04750Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
kegghsa04912GnRH signaling pathway - Homo sapiens (human)
kegghsa04915Estrogen signaling pathway - Homo sapiens (human)
kegghsa04918Thyroid hormone synthesis - Homo sapiens (human)
kegghsa04921Oxytocin signaling pathway - Homo sapiens (human)
kegghsa04922Glucagon signaling pathway - Homo sapiens (human)
kegghsa04924Renin secretion - Homo sapiens (human)
kegghsa04925Aldosterone synthesis and secretion - Homo sapiens (human)
kegghsa04927Cortisol synthesis and secretion - Homo sapiens (human)
kegghsa04934Cushing,s syndrome - Homo sapiens (human)
kegghsa04970Salivary secretion - Homo sapiens (human)
kegghsa04971Gastric acid secretion - Homo sapiens (human)
kegghsa04972Pancreatic secretion - Homo sapiens (human)
kegghsa05010Alzheimer,s disease - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD193Fqi12
iGMDRD201SKI II4
iGMDRD446LY 21832402
iGMDRD375GW-4058332
iGMDRD280CYTOCHALASIN B5
iGMDRD394BX-7956
iGMDRD425ERASTIN3
iGMDRD579PF7502
iGMDRD1008SR-II-138A7
iGMDRD599Salermide2
iGMDRD889Compound 7d-cis1
iGMDRD126Tipifarnib4
iGMDRD484Pluripotin2
iGMDRD494Neopeltolide1
iGMDRD483SCH-5290744
iGMDRD546BMS-7548072
iGMDRD779PRL-3 Inhibitor I1
iGMDRD144NSC953973
iGMDRD562Navitoclax3
iGMDRD780PP-303
iGMDRD577BIX012942
iGMDRD506Fedratinib5
iGMDRD399Selumetinib1
iGMDRD100Zebularine2
iGMDRD188Piperlongumine4
iGMDRD369TGX-1153
iGMDRD60Quinoclamine2
iGMDRD64Parbendazole1
iGMDRD138PX 122
iGMDRD52Rotenone1
iGMDRD698Neratinib1
iGMDRD499PDMP2
iGMDRD57Chloropentafluorobenzene5
iGMDRD85Ursolic acid1
iGMDRD341Triacsin c2
iGMDRD883CIL55A2
iGMDRD123Isoevodiamine3
iGMDRD901ELCPK2
iGMDRD211(1S,3R)-RSL39
iGMDRD584VER 1550081
iGMDRD512nutlin 32
iGMDRD486Tosedostat1
iGMDRD405PIK-751
iGMDRD583LDN 1931892
iGMDRD49716beta-Bromoandrosterone3
iGMDRD345Compound 10b [PMID: 11504634]4
iGMDRD150RITA2
iGMDRD366PI-1033
iGMDRD286Nsc 6328392
iGMDRD42Vorinostat3
iGMDRD82Quiflapon1
iGMDRD263AACOCF32
iGMDRD246NPC262
iGMDRD300Tozasertib2
iGMDRD158NSC1415401
iGMDRD77Itraconazole1
iGMDRD192CIL563
iGMDRD434BMS-5369245
iGMDRD705Nakiterpiosin2
iGMDRD6AM-5802
iGMDRD289Parthenolide3
iGMDRD221Tamoxifen1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ITPR2

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