JAK3


Summary: The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
Janus kinase 3MIM:600173Ensembl:ENSG00000105639HGNC:HGNC:6193PA2999019p13.11

GO terms in JAK3


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005768endosome
CCTASGO:0005829cytosol
CCIEAGO:0005856cytoskeleton
BPTASGO:0000165MAPK cascade
BPIEAGO:0002250adaptive immune response
BPISSGO:0002731negative regulation of dendritic cell cytokine production
BPTASGO:0006468protein phosphorylation
BPISSGO:0007167enzyme linked receptor protein signaling pathway
BPIBAGO:0007260tyrosine phosphorylation of STAT protein
BPTASGO:0007260tyrosine phosphorylation of STAT protein
BPISSGO:0018108peptidyl-tyrosine phosphorylation
BPIBAGO:0019221cytokine-mediated signaling pathway
BPTASGO:0019221cytokine-mediated signaling pathway
BPIBAGO:0030183B cell differentiation
BPISSGO:0030183B cell differentiation
BPIBAGO:0030218erythrocyte differentiation
BPISSGO:0032693negative regulation of interleukin-10 production
BPISSGO:0032695negative regulation of interleukin-12 production
BPISSGO:0035556intracellular signal transduction
BPTASGO:0035723interleukin-15-mediated signaling pathway
BPIDAGO:0035771interleukin-4-mediated signaling pathway
BPTASGO:0038110interleukin-2-mediated signaling pathway
BPTASGO:0038111interleukin-7-mediated signaling pathway
BPTASGO:0038113interleukin-9-mediated signaling pathway
BPTASGO:0038114interleukin-21-mediated signaling pathway
BPIBAGO:0042102positive regulation of T cell proliferation
BPIBAGO:0042981regulation of apoptotic process
BPIBAGO:0043029T cell homeostasis
BPISSGO:0043029T cell homeostasis
BPTASGO:0043029T cell homeostasis
BPISSGO:0045221negative regulation of FasL biosynthetic process
BPISSGO:0045626negative regulation of T-helper 1 cell differentiation
BPTASGO:0046425regulation of JAK-STAT cascade
BPISSGO:0050868negative regulation of T cell activation
BPTASGO:0060397JAK-STAT cascade involved in growth hormone signaling pathway
BPISSGO:0070232regulation of T cell apoptotic process
BPISSGO:0070244negative regulation of thymocyte apoptotic process
BPTASGO:0070669response to interleukin-2
BPIDAGO:0070670response to interleukin-4
BPTASGO:0070672response to interleukin-15
BPTASGO:0071104response to interleukin-9
MFISSGO:0004713protein tyrosine kinase activity
MFTASGO:0004713protein tyrosine kinase activity
MFTASGO:0005088Ras guanyl-nucleotide exchange factor activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIPIGO:0019903protein phosphatase binding

Gene expression in normal tissue: JAK3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in JAK3


DatabasePathway IDPathway Des.
biocartaher2pathwayrole of erbb2 in signal transduction and oncology
biocartail2pathwayil 2 signaling pathway
biocartail2rbpathwayil-2 receptor beta chain in t cell activation
biocartail4pathwayil 4 signaling pathway
biocartail6pathwayil 6 signaling pathway
biocartail7pathwayil-7 signal transduction
biocartastat3pathwaystat3 signaling pathway
reactomeR-HSA-1266695Interleukin-7 signaling
reactomeR-HSA-1266695Interleukin-7 signaling
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-451927Interleukin-2 family signaling
reactomeR-HSA-451927Interleukin-2 family signaling
reactomeR-HSA-512988Interleukin-3, Interleukin-5 and GM-CSF signaling
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signaling
reactomeR-HSA-8854691Interleukin-20 family signaling
reactomeR-HSA-8983432Interleukin-15 signaling
reactomeR-HSA-8983432Interleukin-15 signaling
reactomeR-HSA-8985947Interleukin-9 signaling
reactomeR-HSA-9020558Interleukin-2 signaling
reactomeR-HSA-9020958Interleukin-21 signaling
reactomeR-HSA-912526Interleukin receptor SHC signaling
wikipathwaysWP205IL-7 Signaling Pathway
wikipathwaysWP22IL-9 Signaling Pathway
wikipathwaysWP2374Oncostatin M Signaling Pathway
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP395IL-4 Signaling Pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4205MET in type 1 papillary renal cell carcinoma
wikipathwaysWP49IL-2 Signaling Pathway
pidcd40_pathwayCD40/CD40L signaling
pidil2_1pathwayIL2-mediated signaling events
pidil2_pi3kpathwayIL2 signaling events mediated by PI3K
pidil2_stat5pathwayIL2 signaling events mediated by STAT5
pidil4_2pathwayIL4-mediated signaling events
pidshp2_pathwaySHP2 signaling
pidtcptp_pathwaySignaling events mediated by TCPTP
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa04658Th1 and Th2 cell differentiation - Homo sapiens (human)
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05340Primary immunodeficiency - Homo sapiens (human)
netpathPathway_IL-7IL-7
netpathPathway_IL2IL2
netpathPathway_IL4IL4
netpathPathway_IL9IL9
netpathPathway_KitReceptorKitReceptor
netpathPathway_LeptinLeptin
netpathPathway_TCRTCR

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD782DC-45-A23
iGMDRD885Compound 1103
iGMDRD52Rotenone3
iGMDRD137Indisulam6
iGMDRD932JAK inhibitor10
iGMDRD353PD03259011
iGMDRD23Gossypol3
iGMDRD100Zebularine3
iGMDRD577BIX012946
iGMDRD780PP-303
iGMDRD382CEP-7011
iGMDRD126Tipifarnib3
iGMDRD48Dexamethasone3
iGMDRD307Manumycin A3
iGMDRD248BRD43543
iGMDRD420Leucascandrolide A3
iGMDRD280CYTOCHALASIN B3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in JAK3

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