KCND1
Summary: This gene encodes a multipass membrane protein that comprises the pore subunit of the voltage-gated A-type potassium channel, which functions in the repolarization of membrane action potentials. Activity of voltage-gated potassium channels is important in a number of physiological processes, among them the regulation of neurotransmitter release, heart rate, insulin secretion, and smooth muscle contraction. [provided by RefSeq, Aug 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| potassium voltage-gated channel subfamily D member 1 | MIM:300281 | Ensembl:ENSG00000102057 | HGNC:HGNC:6237 | PA30029 | Xp11.23 |
GO terms in KCND1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005249 | voltage-gated potassium channel activity |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | IEA | GO:0034765 | regulation of ion transmembrane transport |
| BP | IEA | GO:0051260 | protein homooligomerization |
| BP | IBA | GO:0071805 | potassium ion transmembrane transport |
| BP | IEA | GO:0071805 | potassium ion transmembrane transport |
| CC | ND | GO:0005575 | cellular_component |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0008076 | voltage-gated potassium channel complex |
| CC | IEA | GO:0008076 | voltage-gated potassium channel complex |
| CC | IBA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0030425 | dendrite |
| CC | IEA | GO:0043025 | neuronal cell body |
Gene expression in normal tissue: KCND1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KCND1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1296071 | Potassium Channels |
| reactome | R-HSA-1296072 | Voltage gated Potassium channels |
| reactome | R-HSA-397014 | Muscle contraction |
| reactome | R-HSA-5576891 | Cardiac conduction |
| reactome | R-HSA-5576894 | Phase 1 - inactivation of fast Na+ channels |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KCND1
CLASSFICATION
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