Summary: This gene encodes a member of the TWIK-related arachidonic acid-stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primarily in neural tissues and may be involved in regulating the noxious input threshold in dorsal root ganglia neurons. Alternate splicing results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream testis expressed 40 (TEX40) gene, as represented in GeneID: 106780802. [provided by RefSeq, Nov 2015].

potassium two pore domain channel subfamily K member 4MIM:605720Ensembl:ENSG00000182450HGNC:HGNC:6279PA3006111q13.1

GO terms in KCNK4

Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCIMPGO:0005887integral component of plasma membrane
CCISSGO:0005887integral component of plasma membrane
CCIDAGO:0034705potassium channel complex
BPTASGO:0006813potassium ion transport
BPISSGO:0019233sensory perception of pain
BPIBAGO:0030322stabilization of membrane potential
BPIEAGO:0034765regulation of ion transmembrane transport
BPISSGO:0050951sensory perception of temperature stimulus
BPISSGO:0050976detection of mechanical stimulus involved in sensory perception of touch
BPIDAGO:0071260cellular response to mechanical stimulus
BPIDAGO:0071398cellular response to fatty acid
BPISSGO:0071469cellular response to alkaline pH
BPISSGO:0071502cellular response to temperature stimulus
BPIBAGO:0071805potassium ion transmembrane transport
BPIDAGO:0071805potassium ion transmembrane transport
MFIEAGO:0005244voltage-gated ion channel activity
MFIDAGO:0005267potassium channel activity
MFIBAGO:0022841potassium ion leak channel activity
MFISSGO:0097604temperature-gated cation channel activity
MFIDAGO:0098782mechanosensitived potassium channel activity

Gene expression in normal tissue: KCNK4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KCNK4

DatabasePathway IDPathway Des.
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1296071Potassium Channels
reactomeR-HSA-1296346Tandem pore domain potassium channels
reactomeR-HSA-1299503TWIK related potassium channel (TREK)
reactomeR-HSA-397014Muscle contraction
reactomeR-HSA-5576886Phase 4 - resting membrane potential
reactomeR-HSA-5576891Cardiac conduction

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KCNK4