KCNMB4
Summary: MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| potassium calcium-activated channel subfamily M regulatory beta subunit 4 | MIM:605223 | Ensembl:ENSG00000135643 | HGNC:HGNC:6289 | PA30069 | 12q15 |
GO terms in KCNMB4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0015269 | calcium-activated potassium channel activity |
| MF | IDA | GO:0015269 | calcium-activated potassium channel activity |
| MF | IBA | GO:0015459 | potassium channel regulator activity |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0008076 | voltage-gated potassium channel complex |
| CC | IDA | GO:0008076 | voltage-gated potassium channel complex |
| BP | IDA | GO:0001508 | action potential |
| BP | IBA | GO:0005513 | detection of calcium ion |
| BP | IDA | GO:0005513 | detection of calcium ion |
| BP | IDA | GO:0006813 | potassium ion transport |
| BP | TAS | GO:0007268 | chemical synaptic transmission |
| BP | IDA | GO:0019228 | neuronal action potential |
| BP | TAS | GO:0019229 | regulation of vasoconstriction |
| BP | TAS | GO:0046928 | regulation of neurotransmitter secretion |
| BP | IEA | GO:0071805 | potassium ion transmembrane transport |
Gene expression in normal tissue: KCNMB4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KCNMB4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| kegg | hsa04911 | Insulin secretion - Homo sapiens (human) |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1296052 | Ca2+ activated K+ channels |
| reactome | R-HSA-1296071 | Potassium Channels |
| reactome | R-HSA-392154 | Nitric oxide stimulates guanylate cyclase |
| reactome | R-HSA-418346 | Platelet homeostasis |
| reactome | R-HSA-418457 | cGMP effects |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KCNMB4
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