Summary: MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. [provided by RefSeq, Jul 2008].

potassium calcium-activated channel subfamily M regulatory beta subunit 4MIM:605223Ensembl:ENSG00000135643HGNC:HGNC:6289PA3006912q15

Gene Categories:


GO terms in KCNMB4

Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIBAGO:0015269calcium-activated potassium channel activity
MFIDAGO:0015269calcium-activated potassium channel activity
MFIBAGO:0015459potassium channel regulator activity
CCTASGO:0005886plasma membrane
CCIDAGO:0005887integral component of plasma membrane
CCIBAGO:0008076voltage-gated potassium channel complex
CCIDAGO:0008076voltage-gated potassium channel complex
BPIDAGO:0001508action potential
BPIBAGO:0005513detection of calcium ion
BPIDAGO:0005513detection of calcium ion
BPIDAGO:0006813potassium ion transport
BPTASGO:0007268chemical synaptic transmission
BPIDAGO:0019228neuronal action potential
BPTASGO:0019229regulation of vasoconstriction
BPTASGO:0046928regulation of neurotransmitter secretion
BPIEAGO:0071805potassium ion transmembrane transport

Gene expression in normal tissue: KCNMB4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KCNMB4

DatabasePathway IDPathway Des.
kegghsa04022cGMP-PKG signaling pathway - Homo sapiens (human)
kegghsa04270Vascular smooth muscle contraction - Homo sapiens (human)
kegghsa04911Insulin secretion - Homo sapiens (human)
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1296052Ca2+ activated K+ channels
reactomeR-HSA-1296071Potassium Channels
reactomeR-HSA-392154Nitric oxide stimulates guanylate cyclase
reactomeR-HSA-418346Platelet homeostasis
reactomeR-HSA-418457cGMP effects

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KCNMB4