KLHL13
Summary: This gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and other proteins to form the Cullin 3-based E3 ubiquitin-protein ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| kelch like family member 13 | MIM:300655 | Ensembl:ENSG00000003096 | HGNC:HGNC:22931 | PA134959204 | Xq24 |
Gene Categories:
DRUGGABLE GENOMEGO terms in KLHL13
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0030496 | midbody |
| CC | IDA | GO:0031463 | Cul3-RING ubiquitin ligase complex |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IDA | GO:0016567 | protein ubiquitination |
| BP | IEA | GO:0016567 | protein ubiquitination |
| BP | IMP | GO:0032465 | regulation of cytokinesis |
| BP | TAS | GO:0043687 | post-translational protein modification |
| BP | IEA | GO:0051301 | cell division |
| MF | IDA | GO:0004842 | ubiquitin-protein transferase activity |
Gene expression in normal tissue: KLHL13
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KLHL13
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04120 | Ubiquitin mediated proteolysis - Homo sapiens (human) |
| pid | aurora_b_pathway | Aurora B signaling |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-8951664 | Neddylation |
| reactome | R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KLHL13
CLASSFICATION
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