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LCP2

Summary: This gene encodes an adapter protein that acts as a substrate of the T cell antigen receptor (TCR)-activated protein tyrosine kinase pathway. The encoded protein associates with growth factor receptor bound protein 2, and is thought to play a role TCR-mediated intracellular signal transduction. A similar protein in mouse plays a role in normal T-cell development and activation. Mice lacking this gene show subcutaneous and intraperitoneal fetal hemorrhaging, dysfunctional platelets and impaired viability. [provided by RefSeq, Nov 2016].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
lymphocyte cytosolic protein 2	MIM:601603	Ensembl:ENSG00000043462	HGNC:HGNC:6529	PA30313	5q35.1

Gene Categories:

KINASE

GO terms in LCP2

Term Type	Evidence Type	GO Term ID	GO Des.
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol
CC	IEA	GO:0005911	cell-cell junction
CC	IDA	GO:0036398	TCR signalosome
CC	IDA	GO:0044853	plasma membrane raft
BP	TAS	GO:0006955	immune response
BP	IBA	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
BP	TAS	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
BP	TAS	GO:0030168	platelet activation
BP	IBA	GO:0035556	intracellular signal transduction
BP	TAS	GO:0038095	Fc-epsilon receptor signaling pathway
BP	IEA	GO:0045576	mast cell activation
BP	IEP	GO:0045860	positive regulation of protein kinase activity
BP	IEA	GO:0050663	cytokine secretion
BP	IDA	GO:0050852	T cell receptor signaling pathway
BP	TAS	GO:0050852	T cell receptor signaling pathway
MF	IPI	GO:0005515	protein binding

Gene expression in normal tissue: LCP2

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LCP2

Database	Pathway ID	Pathway Des.
netpath	Pathway_BCR	BCR
netpath	Pathway_TCR	TCR
pid	cd8tcrpathway	TCR signaling in naïve CD8+ T cells
pid	fcer1pathway	Fc-epsilon receptor I signaling in mast cells
pid	tcr_pathway	TCR signaling in naïve CD4+ T cells
pid	tcrjnkpathway	JNK signaling in the CD4+ TCR pathway
kegg	hsa04015	Rap1 signaling pathway - Homo sapiens (human)
kegg	hsa04380	Osteoclast differentiation - Homo sapiens (human)
kegg	hsa04611	Platelet activation - Homo sapiens (human)
kegg	hsa04650	Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegg	hsa04660	T cell receptor signaling pathway - Homo sapiens (human)
kegg	hsa04664	Fc epsilon RI signaling pathway - Homo sapiens (human)
smpdb	SMP00358	Fc Epsilon Receptor I Signaling in Mast Cells
wikipathways	WP3863	T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection
wikipathways	WP69	T-Cell antigen Receptor (TCR) Signaling Pathway
reactome	R-HSA-109582	Hemostasis
reactome	R-HSA-114604	GPVI-mediated activation cascade
reactome	R-HSA-1280218	Adaptive Immune System
reactome	R-HSA-1280218	Adaptive Immune System
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-202403	TCR signaling
reactome	R-HSA-202403	TCR signaling
reactome	R-HSA-202433	Generation of second messenger molecules
reactome	R-HSA-202433	Generation of second messenger molecules
reactome	R-HSA-2172127	DAP12 interactions
reactome	R-HSA-2424491	DAP12 signaling
reactome	R-HSA-2454202	Fc epsilon receptor (FCERI) signaling
reactome	R-HSA-2454202	Fc epsilon receptor (FCERI) signaling
reactome	R-HSA-2871796	FCERI mediated MAPK activation
reactome	R-HSA-2871809	FCERI mediated Ca+2 mobilization
reactome	R-HSA-2871809	FCERI mediated Ca+2 mobilization
reactome	R-HSA-76002	Platelet activation, signaling and aggregation

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LCP2

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DATATYPES

CLASSFICATION

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