LZTS1
Summary: This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| leucine zipper tumor suppressor 1 | MIM:606551 | Ensembl:ENSG00000061337 | HGNC:HGNC:13861 | PA30507 | 8p21.3 |
GO terms in LZTS1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | NAS | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IMP | GO:0016242 | negative regulation of macroautophagy |
| BP | IEA | GO:0044772 | mitotic cell cycle phase transition |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0014069 | postsynaptic density |
| CC | IEA | GO:0030054 | cell junction |
| CC | IEA | GO:0043197 | dendritic spine |
| CC | IEA | GO:0045211 | postsynaptic membrane |
| MF | NAS | GO:0003677 | DNA binding |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008017 | microtubule binding |
Gene expression in normal tissue: LZTS1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LZTS1
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LZTS1
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