MAFG
Summary: Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160).[supplied by OMIM, Mar 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| MAF bZIP transcription factor G | MIM:602020 | Ensembl:ENSG00000197063 | HGNC:HGNC:6781 | PA30539 | 17q25.3 |
GO terms in MAFG
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0007596 | blood coagulation |
| BP | IEA | GO:0030534 | adult behavior |
| BP | IEA | GO:0030641 | regulation of cellular pH |
| BP | IEA | GO:0042127 | regulation of cell proliferation |
| BP | IEA | GO:0045604 | regulation of epidermal cell differentiation |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| CC | TAS | GO:0005654 | nucleoplasm |
| MF | IEA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | NAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
Gene expression in normal tissue: MAFG
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAFG
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | arenrf2pathway | oxidative stress induced gene expression via nrf2 |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-983231 | Factors involved in megakaryocyte development and platelet production |
| reactome | R-HSA-983231 | Factors involved in megakaryocyte development and platelet production |
| wikipathways | WP2435 | Quercetin and Nf-kB- AP-1 Induced Cell Apoptosis |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP2884 | NRF2 pathway |
| pharmgkb | PA165985892 | Tacrolimus/Cyclosporine Pathway, Pharmacodynamics |
| pid | ap1_pathway | AP-1 transcription factor network |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAFG
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