MAPK8IP2
Summary: This gene encodes a scaffold protein that is thought to be involved in the regulation of the c-Jun amino-terminal kinase signaling pathway. This protein has been shown to interact with and regulate the activity of MAPK8/JNK1 and MAP2K7/MKK7 kinases. [provided by RefSeq, Jun 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mitogen-activated protein kinase 8 interacting protein 2 | MIM:607755 | Ensembl:ENSG00000008735 | HGNC:HGNC:6883 | PA30627 | 22q13.33 |
GO terms in MAPK8IP2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0001662 | behavioral fear response |
| BP | TAS | GO:0007172 | signal complex assembly |
| BP | IEA | GO:0007254 | JNK cascade |
| BP | IEA | GO:0007617 | mating behavior |
| BP | ISS | GO:0010469 | regulation of signaling receptor activity |
| BP | IEA | GO:0032874 | positive regulation of stress-activated MAPK cascade |
| BP | ISS | GO:0035176 | social behavior |
| BP | IDA | GO:0046328 | regulation of JNK cascade |
| BP | ISS | GO:0046958 | nonassociative learning |
| BP | ISS | GO:0048813 | dendrite morphogenesis |
| BP | ISS | GO:0051966 | regulation of synaptic transmission, glutamatergic |
| BP | ISS | GO:0060079 | excitatory postsynaptic potential |
| BP | ISS | GO:2000310 | regulation of NMDA receptor activity |
| BP | ISS | GO:2000311 | regulation of AMPA receptor activity |
| BP | IDA | GO:2001234 | negative regulation of apoptotic signaling pathway |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0014069 | postsynaptic density |
| CC | IEA | GO:0032991 | protein-containing complex |
| CC | IEA | GO:0043025 | neuronal cell body |
| MF | NAS | GO:0001540 | amyloid-beta binding |
| MF | IDA | GO:0005078 | MAP-kinase scaffold activity |
| MF | NAS | GO:0005078 | MAP-kinase scaffold activity |
| MF | TAS | GO:0005198 | structural molecule activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0019894 | kinesin binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IEA | GO:0044877 | protein-containing complex binding |
Gene expression in normal tissue: MAPK8IP2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAPK8IP2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP382 | MAPK Signaling Pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD506 | Fedratinib | 6 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD885 | Compound 110 | 6 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD639 | YK 4-279 | 1 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD772 | BRD4770 | 5 |
| iGMDRD148 | Pifithrin-mu | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAPK8IP2
CLASSFICATION
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