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MARK4

Summary: This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
microtubule affinity regulating kinase 4	MIM:606495	Ensembl:ENSG00000007047	HGNC:HGNC:13538	PA30641	19q13.32

Gene Categories:

DRUGGABLE GENOME SERINE THREONINE KINASE KINASE

GO terms in MARK4

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IBA	GO:0004674	protein serine/threonine kinase activity
MF	IDA	GO:0004674	protein serine/threonine kinase activity
MF	NAS	GO:0004674	protein serine/threonine kinase activity
MF	IPI	GO:0005515	protein binding
MF	NAS	GO:0005524	ATP binding
MF	IDA	GO:0008017	microtubule binding
MF	IDA	GO:0043015	gamma-tubulin binding
MF	NAS	GO:0043130	ubiquitin binding
MF	IBA	GO:0050321	tau-protein kinase activity
MF	IDA	GO:0050321	tau-protein kinase activity
MF	IMP	GO:0050321	tau-protein kinase activity
CC	IDA	GO:0000930	gamma-tubulin complex
CC	IBA	GO:0005737	cytoplasm
CC	IDA	GO:0005737	cytoplasm
CC	IDA	GO:0005813	centrosome
CC	IDA	GO:0005815	microtubule organizing center
CC	TAS	GO:0005829	cytosol
CC	IDA	GO:0015630	microtubule cytoskeleton
CC	IDA	GO:0030425	dendrite
CC	IDA	GO:0030496	midbody
CC	IMP	GO:0036064	ciliary basal body
CC	IDA	GO:0043005	neuron projection
BP	IBA	GO:0000226	microtubule cytoskeleton organization
BP	IMP	GO:0000226	microtubule cytoskeleton organization
BP	IMP	GO:0000226	microtubule cytoskeleton organization
BP	IEP	GO:0001578	microtubule bundle formation
BP	IMP	GO:0006468	protein phosphorylation
BP	TAS	GO:0006468	protein phosphorylation
BP	IEA	GO:0007049	cell cycle
BP	IDA	GO:0007399	nervous system development
BP	IBA	GO:0035556	intracellular signal transduction
BP	NAS	GO:0043068	positive regulation of programmed cell death
BP	IGI	GO:0044782	cilium organization
BP	IMP	GO:0045724	positive regulation of cilium assembly
BP	IMP	GO:0046605	regulation of centrosome cycle
BP	IEA	GO:0051301	cell division
BP	TAS	GO:0097711	ciliary basal body-plasma membrane docking
BP	IMP	GO:1904781	positive regulation of protein localization to centrosome

Gene expression in normal tissue: MARK4

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MARK4

Database	Pathway ID	Pathway Des.
pid	lkb1_pathway	LKB1 signaling events
reactome	R-HSA-1852241	Organelle biogenesis and maintenance
reactome	R-HSA-5617833	Cilium Assembly
reactome	R-HSA-5620912	Anchoring of the basal body to the plasma membrane

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD105	Triptolide	6
iGMDRD294	Batimastat	2
iGMDRD77	Itraconazole	2
iGMDRD138	PX 12	3
iGMDRD121	GMX1778	2
iGMDRD251	ML162	3
iGMDRD103	SN-38	6
iGMDRD255	SB225002	3
iGMDRD369	TGX-115	2
iGMDRD263	AACOCF3	2
iGMDRD505	Pevonedistat	4
iGMDRD524	ISX-9	1
iGMDRD414	MST-312	5
iGMDRD286	Nsc 632839	4
iGMDRD188	Piperlongumine	4
iGMDRD780	PP-30	2
iGMDRD506	Fedratinib	2
iGMDRD144	NSC95397	4
iGMDRD546	BMS-754807	3
iGMDRD424	Tamatinib	5
iGMDRD116	CD437	2
iGMDRD297	Austocystin D	4
iGMDRD446	LY 2183240	4
iGMDRD61	Kinetin riboside	3
iGMDRD152	179324-69-7	3
iGMDRD57	Chloropentafluorobenzene	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MARK4

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DATATYPES

CLASSFICATION

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