MELK
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| maternal embryonic leucine zipper kinase | MIM:607025 | Ensembl:ENSG00000165304 | HGNC:HGNC:16870 | PA134902874 | 9p13.2 |
GO terms in MELK
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005938 | cell cortex |
| CC | HDA | GO:0016020 | membrane |
| BP | TAS | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0006915 | apoptotic process |
| BP | IDA | GO:0008283 | cell proliferation |
| BP | IEA | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | ISS | GO:0030097 | hemopoiesis |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | ISS | GO:0043065 | positive regulation of apoptotic process |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | ISS | GO:0061351 | neural precursor cell proliferation |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | IDA | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | IDA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0008289 | lipid binding |
Gene expression in normal tissue: MELK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MELK
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD52 | Rotenone | 1 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD60 | Quinoclamine | 1 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD945 | ML214 | 1 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD398 | Sepantronium | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MELK
CLASSFICATION
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