MIR584


Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
microRNA 584Ensembl:ENSG00000207714HGNC:HGNC:32840PA1647228815q32

GO terms in MIR584


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0000993RNA polymerase II core binding
BPIEAGO:0035195gene silencing by miRNA
CCHDAGO:0005615extracellular space
CCIEAGO:0035068micro-ribonucleoprotein complex

Gene expression in normal tissue: MIR584

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MIR584


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MIR584

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