MMP24
Summary: This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. Unlike most MMPs, which are secreted, this protease is a member of the membrane-type MMP (MT-MMP) subfamily, contains a transmembrane domain and is expressed at the cell surface. Substrates of this protease include the proteins cadherin 2 and matrix metallopeptidase 2 (also known as 72 kDa type IV collagenase). [provided by RefSeq, Feb 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| matrix metallopeptidase 24 | MIM:604871 | Ensembl:ENSG00000125966 | HGNC:HGNC:7172 | PA30881 | 20q11.22 |
GO terms in MMP24
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0004222 | metalloendopeptidase activity |
| MF | TAS | GO:0008047 | enzyme activator activity |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IEA | GO:0045296 | cadherin binding |
| BP | ISS | GO:0006508 | proteolysis |
| BP | ISS | GO:0010001 | glial cell differentiation |
| BP | IEA | GO:0043085 | positive regulation of catalytic activity |
| BP | ISS | GO:0044331 | cell-cell adhesion mediated by cadherin |
| BP | ISS | GO:0050965 | detection of temperature stimulus involved in sensory perception of pain |
| BP | ISS | GO:0097150 | neuronal stem cell population maintenance |
| BP | ISS | GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules |
| CC | ISS | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0031012 | extracellular matrix |
| CC | ISS | GO:0032588 | trans-Golgi network membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: MMP24
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MMP24
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP129 | Matrix Metalloproteinases |
| reactome | R-HSA-1474228 | Degradation of the extracellular matrix |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1592389 | Activation of Matrix Metalloproteinases |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MMP24
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