MMP8
Summary: This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| matrix metallopeptidase 8 | MIM:120355 | Ensembl:ENSG00000118113 | HGNC:HGNC:7175 | PA30888 | 11q22.2 |
GO terms in MMP8
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004222 | metalloendopeptidase activity |
| MF | IDA | GO:0004252 | serine-type endopeptidase activity |
| MF | TAS | GO:0004252 | serine-type endopeptidase activity |
| MF | TAS | GO:0008270 | zinc ion binding |
| BP | IDA | GO:0006508 | proteolysis |
| BP | TAS | GO:0022617 | extracellular matrix disassembly |
| BP | TAS | GO:0030574 | collagen catabolic process |
| BP | IEP | GO:0035987 | endodermal cell differentiation |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IEA | GO:0031012 | extracellular matrix |
| CC | TAS | GO:0035580 | specific granule lumen |
| CC | TAS | GO:1904724 | tertiary granule lumen |
Gene expression in normal tissue: MMP8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MMP8
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP129 | Matrix Metalloproteinases |
| reactome | R-HSA-1442490 | Collagen degradation |
| reactome | R-HSA-1474228 | Degradation of the extracellular matrix |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1592389 | Activation of Matrix Metalloproteinases |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD584 | VER 155008 | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD494 | Neopeltolide | 6 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD251 | ML162 | 2 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD434 | BMS-536924 | 5 |
| iGMDRD506 | Fedratinib | 5 |
| iGMDRD366 | PI-103 | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD300 | Tozasertib | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MMP8
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