MNX1
Summary: This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| motor neuron and pancreas homeobox 1 | MIM:142994 | Ensembl:ENSG00000130675 | HGNC:HGNC:4979 | PA162396041 | 7q36.3 |
GO terms in MNX1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IEA | GO:0043565 | sequence-specific DNA binding |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005829 | cytosol |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | TAS | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0006959 | humoral immune response |
| BP | TAS | GO:0009653 | anatomical structure morphogenesis |
| BP | IBA | GO:0021520 | spinal cord motor neuron cell fate specification |
| BP | IBA | GO:0031018 | endocrine pancreas development |
| BP | IBA | GO:0048812 | neuron projection morphogenesis |
Gene expression in normal tissue: MNX1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MNX1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04950 | Maturity onset diabetes of the young - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD577 | BIX01294 | 6 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD945 | ML214 | 6 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD427 | ABT737 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MNX1
CLASSFICATION
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