MRPL16
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mitochondrial ribosomal protein L16 | MIM:611829 | Ensembl:ENSG00000166902 | HGNC:HGNC:14476 | PA30945 | 11q12.1 |
GO terms in MRPL16
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0003735 | structural constituent of ribosome |
| MF | IBA | GO:0019843 | rRNA binding |
| CC | TAS | GO:0005743 | mitochondrial inner membrane |
| CC | IBA | GO:0005762 | mitochondrial large ribosomal subunit |
| CC | IDA | GO:0005762 | mitochondrial large ribosomal subunit |
| BP | IBA | GO:0032543 | mitochondrial translation |
| BP | TAS | GO:0070125 | mitochondrial translational elongation |
| BP | TAS | GO:0070126 | mitochondrial translational termination |
Gene expression in normal tissue: MRPL16
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MRPL16
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5368286 | Mitochondrial translation initiation |
| reactome | R-HSA-5368287 | Mitochondrial translation |
| reactome | R-HSA-5368287 | Mitochondrial translation |
| reactome | R-HSA-5389840 | Mitochondrial translation elongation |
| reactome | R-HSA-5389840 | Mitochondrial translation elongation |
| reactome | R-HSA-5419276 | Mitochondrial translation termination |
| reactome | R-HSA-72766 | Translation |
| reactome | R-HSA-72766 | Translation |
| kegg | hsa03010 | Ribosome - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MRPL16
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