Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008].

mitochondrial ribosomal protein L16MIM:611829Ensembl:ENSG00000166902HGNC:HGNC:14476PA3094511q12.1

GO terms in MRPL16

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0003735structural constituent of ribosome
MFIBAGO:0019843rRNA binding
CCTASGO:0005743mitochondrial inner membrane
CCIBAGO:0005762mitochondrial large ribosomal subunit
CCIDAGO:0005762mitochondrial large ribosomal subunit
BPIBAGO:0032543mitochondrial translation
BPTASGO:0070125mitochondrial translational elongation
BPTASGO:0070126mitochondrial translational termination

Gene expression in normal tissue: MRPL16

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MRPL16

DatabasePathway IDPathway Des.
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5368286Mitochondrial translation initiation
reactomeR-HSA-5368287Mitochondrial translation
reactomeR-HSA-5368287Mitochondrial translation
reactomeR-HSA-5389840Mitochondrial translation elongation
reactomeR-HSA-5389840Mitochondrial translation elongation
reactomeR-HSA-5419276Mitochondrial translation termination
kegghsa03010Ribosome - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MRPL16