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MSI2

Summary: This gene encodes an RNA-binding protein that is a member of the Musashi protein family. The encoded protein is transcriptional regulator that targets genes involved in development and cell cycle regulation. Mutations in this gene are associated with poor prognosis in certain types of cancers. This gene has also been shown to be rearranged in certain cancer cells. [provided by RefSeq, Apr 2016].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
musashi RNA binding protein 2	MIM:607897	Ensembl:ENSG00000153944	HGNC:HGNC:18585	PA38590	17q22

GO terms in MSI2

Term Type	Evidence Type	GO Term ID	GO Des.
MF	HDA	GO:0003723	RNA binding
MF	IBA	GO:0003723	RNA binding
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0008266	poly(U) RNA binding
BP	IEA	GO:0048864	stem cell development
BP	IBA	GO:0051252	regulation of RNA metabolic process
CC	IBA	GO:0005634	nucleus
CC	IBA	GO:0005654	nucleoplasm
CC	IBA	GO:0005737	cytoplasm
CC	IEA	GO:0005737	cytoplasm
CC	IBA	GO:0005844	polysome
CC	IEA	GO:0005844	polysome

Gene expression in normal tissue: MSI2

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MSI2

Database	Pathway ID	Pathway Des.
wikipathways	WP2004	miR-targeted genes in lymphocytes - TarBase
kegg	hsa03015	mRNA surveillance pathway - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD280	CYTOCHALASIN B	3
iGMDRD318	PAC-1	3
iGMDRD871	BRD6368	3
iGMDRD126	Tipifarnib	6

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MSI2

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DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.