NCOA4
Summary: This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nuclear receptor coactivator 4 | MIM:601984 | Ensembl:ENSG00000266412 | HGNC:HGNC:7671 | PA31473 | 10q11.22 |
GO terms in NCOA4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | NAS | GO:0003713 | transcription coactivator activity |
| MF | NAS | GO:0050681 | androgen receptor binding |
| CC | TAS | GO:0005634 | nucleus |
| CC | IDA | GO:0044754 | autolysosome |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IDA | GO:0006622 | protein targeting to lysosome |
| BP | IEA | GO:0006879 | cellular iron ion homeostasis |
| BP | TAS | GO:0008584 | male gonad development |
| BP | NAS | GO:0030521 | androgen receptor signaling pathway |
| BP | NAS | GO:0045893 | positive regulation of transcription, DNA-templated |
Gene expression in normal tissue: NCOA4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NCOA4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| pid | ar_pathway | Coregulation of Androgen receptor activity |
| kegg | hsa04216 | Ferroptosis - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05216 | Thyroid cancer - Homo sapiens (human) |
| wikipathways | WP138 | Androgen receptor signaling pathway |
| wikipathways | WP410 | Exercise-induced Circadian Regulation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD67 | PENFLURIDOL | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD366 | PI-103 | 3 |
| iGMDRD269 | Purmorphamine | 1 |
| iGMDRD577 | BIX01294 | 1 |
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD192 | CIL56 | 3 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD152 | 179324-69-7 | 5 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD210 | AC55649 | 1 |
| iGMDRD512 | nutlin 3 | 6 |
| iGMDRD701 | NVP-AUY922 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NCOA4
CLASSFICATION
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