NECTIN4
Summary: This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nectin cell adhesion molecule 4 | MIM:609607 | Ensembl:ENSG00000143217 | HGNC:HGNC:19688 | PA134991624 | 1q23.3 |
Gene Categories:
DRUGGABLE GENOMEGO terms in NECTIN4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0001618 | virus receptor activity |
| MF | IBA | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IBA | GO:0042803 | protein homodimerization activity |
| MF | IBA | GO:0050839 | cell adhesion molecule binding |
| BP | IBA | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules |
| BP | IBA | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules |
| BP | IBA | GO:0008037 | cell recognition |
| BP | TAS | GO:0034332 | adherens junction organization |
| BP | IEA | GO:0046718 | viral entry into host cell |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005913 | cell-cell adherens junction |
| CC | IDA | GO:0005913 | cell-cell adherens junction |
| CC | IBA | GO:0043296 | apical junction complex |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: NECTIN4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NECTIN4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-418990 | Adherens junctions interactions |
| reactome | R-HSA-420597 | Nectin/Necl trans heterodimerization |
| reactome | R-HSA-421270 | Cell-cell junction organization |
| reactome | R-HSA-446728 | Cell junction organization |
| kegg | hsa04520 | Adherens junction - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NECTIN4
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