NEDD9
Summary: The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| neural precursor cell expressed, developmentally down-regulated 9 | MIM:602265 | Ensembl:ENSG00000111859 | HGNC:HGNC:7733 | PA31538 | 6p24.2 |
GO terms in NEDD9
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0000922 | spindle pole |
| CC | TAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005794 | Golgi apparatus |
| CC | TAS | GO:0005819 | spindle |
| CC | IDA | GO:0005829 | cytosol |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005925 | focal adhesion |
| CC | IEA | GO:0005938 | cell cortex |
| CC | IEA | GO:0030027 | lamellipodium |
| BP | NAS | GO:0007010 | cytoskeleton organization |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IBA | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| BP | NAS | GO:0007229 | integrin-mediated signaling pathway |
| BP | IBA | GO:0016477 | cell migration |
| BP | IEA | GO:0040008 | regulation of growth |
| BP | NAS | GO:0051017 | actin filament bundle assembly |
| BP | IEA | GO:0051301 | cell division |
| BP | IBA | GO:0090527 | actin filament reorganization |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: NEDD9
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NEDD9
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_TCR | TCR |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD690 | PRIMA-1MET | 6 |
| iGMDRD255 | SB225002 | 6 |
| iGMDRD137 | Indisulam | 6 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD158 | NSC141540 | 6 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 6 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD781 | Sirolimus | 4 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD532 | Olaparib | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NEDD9
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