NEDD9


Summary: The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
neural precursor cell expressed, developmentally down-regulated 9MIM:602265Ensembl:ENSG00000111859HGNC:HGNC:7733PA315386p24.2

GO terms in NEDD9


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0000922spindle pole
CCTASGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCTASGO:0005737cytoplasm
CCIEAGO:0005794Golgi apparatus
CCTASGO:0005819spindle
CCIDAGO:0005829cytosol
CCIBAGO:0005886plasma membrane
CCIDAGO:0005886plasma membrane
CCIEAGO:0005925focal adhesion
CCIEAGO:0005938cell cortex
CCIEAGO:0030027lamellipodium
BPNASGO:0007010cytoskeleton organization
BPIEAGO:0007049cell cycle
BPIEAGO:0007155cell adhesion
BPTASGO:0007165signal transduction
BPIBAGO:0007169transmembrane receptor protein tyrosine kinase signaling pathway
BPNASGO:0007229integrin-mediated signaling pathway
BPIBAGO:0016477cell migration
BPIEAGO:0040008regulation of growth
BPNASGO:0051017actin filament bundle assembly
BPIEAGO:0051301cell division
BPIBAGO:0090527actin filament reorganization
MFIPIGO:0005515protein binding

Gene expression in normal tissue: NEDD9

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NEDD9


DatabasePathway IDPathway Des.
wikipathwaysWP366TGF-beta Signaling Pathway
netpathPathway_BCRBCR
netpathPathway_EGFR1EGFR1
netpathPathway_TCRTCR

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD188Piperlongumine3
iGMDRD690PRIMA-1MET6
iGMDRD255SB2250026
iGMDRD137Indisulam6
iGMDRD138PX 123
iGMDRD202Curcumin3
iGMDRD158NSC1415406
iGMDRD8012,4-dideoxy-DC-45-A26
iGMDRD870BRD636101
iGMDRD57Chloropentafluorobenzene3
iGMDRD152179324-69-73
iGMDRD446LY 21832403
iGMDRD679Bistramide A2
iGMDRD280CYTOCHALASIN B3
iGMDRD394BX-7953
iGMDRD889Compound 7d-cis3
iGMDRD307Manumycin A3
iGMDRD151CHM-13
iGMDRD781Sirolimus4
iGMDRD79Gemcitabine3
iGMDRD532Olaparib3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NEDD9

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