Summary: This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus. [provided by RefSeq, Jul 2008].

neuronal differentiation 1MIM:601724Ensembl:ENSG00000162992HGNC:HGNC:7762PA315642q31.3

GO terms in NEUROD1

Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0090575RNA polymerase II transcription factor complex
BPIEAGO:0003326pancreatic A cell fate commitment
BPIEAGO:0003329pancreatic PP cell fate commitment
BPIEAGO:0006366transcription by RNA polymerase II
BPIEAGO:0006913nucleocytoplasmic transport
BPIDAGO:0007263nitric oxide mediated signal transduction
BPIMPGO:0009749response to glucose
BPIEAGO:0009952anterior/posterior pattern specification
BPISSGO:0021542dentate gyrus development
BPISSGO:0021549cerebellum development
BPIEAGO:0023019signal transduction involved in regulation of gene expression
BPIDAGO:0030073insulin secretion
BPISSGO:0031018endocrine pancreas development
BPTASGO:0031018endocrine pancreas development
BPISSGO:0035881amacrine cell differentiation
BPISSGO:0035883enteroendocrine cell differentiation
BPIEAGO:0042493response to drug
BPISSGO:0042593glucose homeostasis
BPISSGO:0043065positive regulation of apoptotic process
BPISSGO:0045597positive regulation of cell differentiation
BPISSGO:0045666positive regulation of neuron differentiation
BPISSGO:0045893positive regulation of transcription, DNA-templated
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0046426negative regulation of JAK-STAT cascade
BPISSGO:0048562embryonic organ morphogenesis
BPIEAGO:0048666neuron development
BPISSGO:0048839inner ear development
BPICGO:0050796regulation of insulin secretion
BPIDAGO:0051091positive regulation of DNA-binding transcription factor activity
BPISSGO:0060730regulation of intestinal epithelial structure maintenance
BPISSGO:0071156regulation of cell cycle arrest
BPIEAGO:0071333cellular response to glucose stimulus
BPISSGO:2000675negative regulation of type B pancreatic cell apoptotic process
BPIDAGO:2000679positive regulation of transcription regulatory region DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIPIGO:0001102RNA polymerase II activating transcription factor binding
MFISSGO:0003682chromatin binding
MFIDAGO:0003700DNA-binding transcription factor activity
MFIDAGO:0003713transcription coactivator activity
MFIPIGO:0005515protein binding
MFIPIGO:0008134transcription factor binding
MFIDAGO:0043565sequence-specific DNA binding
MFIDAGO:0046982protein heterodimerization activity
MFIPIGO:0046982protein heterodimerization activity
MFIDAGO:0070888E-box binding

Gene expression in normal tissue: NEUROD1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NEUROD1

DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-186712Regulation of beta-cell development
reactomeR-HSA-186712Regulation of beta-cell development
reactomeR-HSA-210745Regulation of gene expression in beta cells
reactomeR-HSA-210746Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
pharmgkbPA153627758Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics
kegghsa04950Maturity onset diabetes of the young - Homo sapiens (human)
wikipathwaysWP2855Dopaminergic Neurogenesis
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NEUROD1