Summary: This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992).[provided by RefSeq, Jun 2010].

neurexin 2MIM:600566Ensembl:ENSG00000110076HGNC:HGNC:8009PA3178711q13.1

GO terms in NRXN2

Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005886plasma membrane
CCIEAGO:0016021integral component of membrane
BPTASGO:0007158neuron cell-cell adhesion
BPISSGO:0007165signal transduction
BPISSGO:0007268chemical synaptic transmission
BPISSGO:0007269neurotransmitter secretion
BPISSGO:0007416synapse assembly
BPIMPGO:0030534adult behavior
BPIMPGO:0035176social behavior
BPIMPGO:0042297vocal learning
BPIMPGO:0071625vocalization behavior
BPISSGO:0097104postsynaptic membrane assembly
BPISSGO:0097116gephyrin clustering involved in postsynaptic density assembly
BPISSGO:0097118neuroligin clustering involved in postsynaptic membrane assembly
BPISSGO:0097119postsynaptic density protein 95 clustering
MFISSGO:0004888transmembrane signaling receptor activity
MFISSGO:0005246calcium channel regulator activity
MFIEAGO:0046872metal ion binding
MFISSGO:0050839cell adhesion molecule binding
MFISSGO:0097109neuroligin family protein binding

Gene expression in normal tissue: NRXN2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NRXN2

DatabasePathway IDPathway Des.
kegghsa04514Cell adhesion molecules (CAMs) - Homo sapiens (human)
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-6794361Neurexins and neuroligins
reactomeR-HSA-6794361Neurexins and neuroligins
reactomeR-HSA-6794362Protein-protein interactions at synapses
reactomeR-HSA-6794362Protein-protein interactions at synapses

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NRXN2