NRXN2
Summary: This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992).[provided by RefSeq, Jun 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| neurexin 2 | MIM:600566 | Ensembl:ENSG00000110076 | HGNC:HGNC:8009 | PA31787 | 11q13.1 |
GO terms in NRXN2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0098793 | presynapse |
| BP | TAS | GO:0007158 | neuron cell-cell adhesion |
| BP | ISS | GO:0007165 | signal transduction |
| BP | ISS | GO:0007268 | chemical synaptic transmission |
| BP | ISS | GO:0007269 | neurotransmitter secretion |
| BP | ISS | GO:0007416 | synapse assembly |
| BP | IMP | GO:0030534 | adult behavior |
| BP | IMP | GO:0035176 | social behavior |
| BP | IMP | GO:0042297 | vocal learning |
| BP | IMP | GO:0071625 | vocalization behavior |
| BP | ISS | GO:0097104 | postsynaptic membrane assembly |
| BP | ISS | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly |
| BP | ISS | GO:0097118 | neuroligin clustering involved in postsynaptic membrane assembly |
| BP | ISS | GO:0097119 | postsynaptic density protein 95 clustering |
| MF | ISS | GO:0004888 | transmembrane signaling receptor activity |
| MF | ISS | GO:0005246 | calcium channel regulator activity |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | ISS | GO:0050839 | cell adhesion molecule binding |
| MF | ISS | GO:0097109 | neuroligin family protein binding |
Gene expression in normal tissue: NRXN2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NRXN2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04514 | Cell adhesion molecules (CAMs) - Homo sapiens (human) |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-6794361 | Neurexins and neuroligins |
| reactome | R-HSA-6794361 | Neurexins and neuroligins |
| reactome | R-HSA-6794362 | Protein-protein interactions at synapses |
| reactome | R-HSA-6794362 | Protein-protein interactions at synapses |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NRXN2
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