NRXN3
Summary: This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder. [provided by RefSeq, Dec 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| neurexin 3 | MIM:600567 | Ensembl:ENSG00000021645 | HGNC:HGNC:8010 | PA31788 | 14q24.3-q31.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in NRXN3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| BP | TAS | GO:0007158 | neuron cell-cell adhesion |
| BP | IEA | GO:0007165 | signal transduction |
| BP | TAS | GO:0007411 | axon guidance |
| BP | IGI | GO:0007612 | learning |
| BP | IGI | GO:0030534 | adult behavior |
| BP | IGI | GO:0035176 | social behavior |
| BP | IGI | GO:0071625 | vocalization behavior |
| MF | TAS | GO:0038023 | signaling receptor activity |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | TAS | GO:0050839 | cell adhesion molecule binding |
| MF | TAS | GO:0097109 | neuroligin family protein binding |
Gene expression in normal tissue: NRXN3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NRXN3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04514 | Cell adhesion molecules (CAMs) - Homo sapiens (human) |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-6794361 | Neurexins and neuroligins |
| reactome | R-HSA-6794361 | Neurexins and neuroligins |
| reactome | R-HSA-6794362 | Protein-protein interactions at synapses |
| reactome | R-HSA-6794362 | Protein-protein interactions at synapses |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NRXN3
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