Summary: This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder. [provided by RefSeq, Dec 2012].

neurexin 3MIM:600567Ensembl:ENSG00000021645HGNC:HGNC:8010PA3178814q24.3-q31.1

Gene Categories:


GO terms in NRXN3

Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
BPTASGO:0007158neuron cell-cell adhesion
BPIEAGO:0007165signal transduction
BPTASGO:0007411axon guidance
BPIGIGO:0030534adult behavior
BPIGIGO:0035176social behavior
BPIGIGO:0071625vocalization behavior
MFTASGO:0038023signaling receptor activity
MFIEAGO:0046872metal ion binding
MFTASGO:0050839cell adhesion molecule binding
MFTASGO:0097109neuroligin family protein binding

Gene expression in normal tissue: NRXN3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NRXN3

DatabasePathway IDPathway Des.
kegghsa04514Cell adhesion molecules (CAMs) - Homo sapiens (human)
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-6794361Neurexins and neuroligins
reactomeR-HSA-6794361Neurexins and neuroligins
reactomeR-HSA-6794362Protein-protein interactions at synapses
reactomeR-HSA-6794362Protein-protein interactions at synapses

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NRXN3