NTF3
Summary: The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| neurotrophin 3 | MIM:162660 | Ensembl:ENSG00000185652 | HGNC:HGNC:8023 | PA31806 | 12p13.31 |
GO terms in NTF3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IBA | GO:0008021 | synaptic vesicle |
| CC | IBA | GO:0030424 | axon |
| CC | IBA | GO:0030425 | dendrite |
| CC | IBA | GO:0031410 | cytoplasmic vesicle |
| BP | IDA | GO:0000187 | activation of MAPK activity |
| BP | IDA | GO:0002092 | positive regulation of receptor internalization |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IBA | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| BP | IDA | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| BP | IBA | GO:0007267 | cell-cell signaling |
| BP | TAS | GO:0007267 | cell-cell signaling |
| BP | TAS | GO:0007399 | nervous system development |
| BP | IBA | GO:0007422 | peripheral nervous system development |
| BP | IBA | GO:0007613 | memory |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IBA | GO:0021675 | nerve development |
| BP | IDA | GO:0030335 | positive regulation of cell migration |
| BP | IDA | GO:0032148 | activation of protein kinase B activity |
| BP | IDA | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| BP | IBA | GO:0038180 | nerve growth factor signaling pathway |
| BP | IBA | GO:0040011 | locomotion |
| BP | IGI | GO:0042981 | regulation of apoptotic process |
| BP | IBA | GO:0043524 | negative regulation of neuron apoptotic process |
| BP | IBA | GO:0045664 | regulation of neuron differentiation |
| BP | IBA | GO:0048812 | neuron projection morphogenesis |
| BP | IDA | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| BP | IDA | GO:0050732 | negative regulation of peptidyl-tyrosine phosphorylation |
| BP | IBA | GO:0050804 | modulation of chemical synaptic transmission |
| BP | IEA | GO:0050918 | positive chemotaxis |
| BP | IDA | GO:0050930 | induction of positive chemotaxis |
| BP | IDA | GO:0090630 | activation of GTPase activity |
| BP | IDA | GO:2000251 | positive regulation of actin cytoskeleton reorganization |
| MF | TAS | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008083 | growth factor activity |
| MF | IDA | GO:0008083 | growth factor activity |
| MF | IDA | GO:0042056 | chemoattractant activity |
Gene expression in normal tissue: NTF3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NTF3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | mapktrkpathway | Trk receptor signaling mediated by the MAPK pathway |
| pid | p75ntrpathway | p75(NTR)-mediated signaling |
| pid | shp2_pathway | SHP2 signaling |
| pid | trkrpathway | Neurotrophic factor-mediated Trk receptor signaling |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| netpath | Pathway_BDNF | BDNF |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-9006115 | Signaling by NTRK2 (TRKB) |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9025046 | NTF3 activates NTRK2 (TRKB) signaling |
| reactome | R-HSA-9034013 | NTF3 activates NTRK3 signaling |
| reactome | R-HSA-9034013 | NTF3 activates NTRK3 signaling |
| reactome | R-HSA-9034015 | Signaling by NTRK3 (TRKC) |
| reactome | R-HSA-9034015 | Signaling by NTRK3 (TRKC) |
| reactome | R-HSA-9034793 | Activated NTRK3 signals through PLCG1 |
| reactome | R-HSA-9034793 | Activated NTRK3 signals through PLCG1 |
| reactome | R-HSA-9034864 | Activated NTRK3 signals through RAS |
| reactome | R-HSA-9603381 | Activated NTRK3 signals through PI3K |
| reactome | R-HSA-9603381 | Activated NTRK3 signals through PI3K |
| biocarta | erk5pathway | role of erk5 in neuronal survival pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NTF3
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.