NUDT10
Summary: This gene is a member of the nudix (nucleoside diphosphate linked moiety X)-type motif containing family. The encoded protein is a phosphohydrolase and may regulate the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to the regulation of intracellular trafficking. In some populations putative prostate cancer susceptibility alleles have been identified for this gene. Alternatively spliced transcript variants, which differ only in the 5' UTR, have been found for this gene. [provided by RefSeq, Feb 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nudix hydrolase 10 | MIM:300527 | Ensembl:ENSG00000122824 | HGNC:HGNC:17621 | PA31831 | Xp11.22 |
GO terms in NUDT10
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000298 | endopolyphosphatase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008486 | diphosphoinositol-polyphosphate diphosphatase activity |
| MF | ISS | GO:0008486 | diphosphoinositol-polyphosphate diphosphatase activity |
| MF | IBA | GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| MF | IBA | GO:0034431 | bis(5'-adenosyl)-hexaphosphatase activity |
| MF | IBA | GO:0034432 | bis(5'-adenosyl)-pentaphosphatase activity |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IBA | GO:0050072 | m7G(5')pppN diphosphatase activity |
| MF | IEA | GO:0052840 | inositol diphosphate tetrakisphosphate diphosphatase activity |
| MF | TAS | GO:0052841 | inositol bisdiphosphate tetrakisphosphate diphosphatase activity |
| MF | TAS | GO:0052842 | inositol diphosphate pentakisphosphate diphosphatase activity |
| MF | IEA | GO:0052843 | inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity |
| MF | IEA | GO:0052844 | inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity |
| MF | IEA | GO:0052845 | inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity |
| MF | IEA | GO:0052846 | inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity |
| MF | IEA | GO:0052847 | inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity |
| MF | IEA | GO:0052848 | inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity |
| CC | IBA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| BP | TAS | GO:0043647 | inositol phosphate metabolic process |
| BP | IBA | GO:0071543 | diphosphoinositol polyphosphate metabolic process |
| BP | IBA | GO:1901907 | diadenosine pentaphosphate catabolic process |
| BP | IBA | GO:1901909 | diadenosine hexaphosphate catabolic process |
| BP | IBA | GO:1901911 | adenosine 5'-(hexahydrogen pentaphosphate) catabolic process |
Gene expression in normal tissue: NUDT10
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NUDT10
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1483249 | Inositol phosphate metabolism |
| reactome | R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD294 | Batimastat | 1 |
| iGMDRD187 | BRD9876 | 6 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD802 | 4-methylfasudil | 6 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD505 | Pevonedistat | 5 |
| iGMDRD524 | ISX-9 | 6 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD451 | Serdemetan | 5 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD74 | Idarubicin | 4 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD100 | Zebularine | 4 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD366 | PI-103 | 8 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 1 |
| iGMDRD150 | RITA | 2 |
| iGMDRD405 | PIK-75 | 6 |
| iGMDRD1008 | SR-II-138A | 1 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD341 | Triacsin c | 5 |
| iGMDRD193 | Fqi1 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NUDT10
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